Direkt zum Inhalt

Fachbereich Angewandte Naturwissenschaften

Oliver Rauh

Dr. Oliver Rauh

Wissenschaftlicher Mitarbeiter - AG Althaus

Gliederung

Fachbereich Angewandte Naturwissenschaften

Forschungsfelder

  • Ion Channels, Electrophysiology, Kinetic Modelling, Molecular Biology

Standort

Rheinbach

Raum

E104

Adresse

Von-Liebig-Straße 20

53359 Rheinbach

Telefon

+4922418659778

Profil

Unravelling of structure/function correlates in ENaC channels

Research Methods

  • Manual and Automated Whole-Cell Patch-Clamp
  • Planar-Lipid Bilayers
  • (Confocal) Fluorescence Microscopy
  • Kinetic Modelling and Analysis of Ion Channel Function
  • Mammalian Cell Culture, E. coli based Growth and Ion Flux Measurements, Cloning

Lebenslauf

11/2014-5/2018 Doctorate in Biophysics in the High Resolution Ion Channel Dynamics Group of Dr. Indra Schröder, TU Darmstadt, Germany

1/2017-6/2017 Exchange researcher at the Columbia University Medical Center (New York City, NY) in the Molecular Physiology Group of Ph.D. Henry Colecraft

6/2018-8/2023 Postdoctoral researcher in the Membrane Biophysics Group of Prof. Dr. Gerhard Thiel, TU Darmstadt, Germany

9/2023-7/2024 Postdoctoral researcher in the Neurophysiology and Neurosensory Systems Group of Prof. Dr. Bodo Laube, TU Darmstadt, Germany

8/2024-present Postdoctoral researcher in the Physiology Group of Prof. Dr. Mike Althaus, HBRS Rheinbach

Mitgliedschaften

German Biophysical Society (Deutsche Gesellschaft für Biophysik)

Forschungsprojekte

CytoTransport - Mechanismen und Modulation zellulärer Transportprozesse

Im DFG-geförderten Forschungsverbund "CytoTransport" werden Expertisen in Biomedizin, computergestützter Modellierung, Strukturbiologie, Chemie und Materialwissenschaften vereint, um zelluläre Transportmechanismen in Gesundheit und Krankheit zu erforschen. Hierzu arbeiten 9 Arbeitsgruppen aus zwei Hochschulforschungsschwerpunkten zusammen, vertreten durch die beiden Forschungsinstitute IFGA und TREE. Ein übergeordnetes Ziel ist dabei, überlappende Interessen und Expertisen der Institute langfristig zu bündeln.

Projektleitung an der H-BRS

Prof. Dr. Mike Althaus Dr. Karl Kirschner Prof. Dr. Matthias Preller Prof. Dr. Dirk Reith Prof. Dr. Jörn Oliver Sass Prof. Dr. Margit Schulze Prof. Dr. Christopher Volk Prof. Dr. Steffen Witzleben Dr. Katrin Richter

Publikationen

Dr. Oliver Rauh

2026 | 2025 | 2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2015 | 2014

2026

Rene Yufenyuy Lawong, Etang Collins Etang, Fabian May, Philipp Vorrat, Oliver Rauh, Mike Althaus: Guinea pig δβγ-ENaC is locked in an open state and uncoupled from regulation by proteases.
PDF Download (CC BY 4.0) doi:10.1007/s00424-026-03173-0 PMID urn:nbn:de:hbz:1044-opus-95908 BibTeX | RIS

Tobias Schulze, Timon Sprave, Carolin Groebe, Jan Hendrik Krumbach, Magnus Behringer, Andre Bazzone, Rocco Zerlotti, Niels Fertig, Mike Althaus, Kay Hamacher, Gerhard Thiel, Christian Grimm, Oliver Rauh: Proton-selective conductance and gating of the lysosomal cation channel TMEM175.
PDF Download (CC BY 4.0) doi:10.1073/pnas.2503909123 PMID urn:nbn:de:hbz:1044-opus-94140 BibTeX | RIS

2025

Oliver Rauh, Tobias Schulze, James L. van Etten, Gerhard Thiel, Anna Moroni: Modular architecture of K+ channels: the functional plasticity of the pore module.
PDF Download (CC BY 4.0) doi:10.1038/s44319-025-00519-0 PMID urn:nbn:de:hbz:1044-opus-91115 BibTeX | RIS

Kerri Kurkovetz, Matea Cartolano, Manuela Gebhardt, Lars E. Schumann, Stefan M. Kast, Anna Moroni, Gerhard Thiel, Oliver Rauh: Yeast complementation assays provide limited informationon functional features of K+ channels.
PDF Download (CC BY 4.0) doi:10.1016/j.bpr.2025.100206 PMID urn:nbn:de:hbz:1044-opus-89335 BibTeX | RIS

Tobias Schulze, Oliver Rauh, Gerhard Thiel, Niels Fertig, Andre Bazzone, Christian Grimm: Unraveling pH Regulation of TMEM175, an Endolysosomal Cation Channel With a Role in Parkinson's Disease.
PDF Download (CC BY 4.0) doi:10.1002/jcp.70008 urn:nbn:de:hbz:1044-opus-88785 PMID BibTeX | RIS

2024

Tobias Schulze, Timon Sprave, Carolin Groebe, Jan Krumbach, Magnus Behringer, Kay Hamacher, Gerhard Thiel, Christian Grimm, Oliver Rauh: Proton selective conductance and gating of lysosomal cation channel TMEM175.
doi:10.1101/2024.11.01.621492 BibTeX | RIS

Noel Tewes, Beatrice Kubitzki, Flandrit Bytyqi, Nikola Metko, Sebastian Mach, Gerhard Thiel, Oliver Rauh: Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore.
doi:10.1085/jgp.202313514 PMID BibTeX | RIS

Klara Eisenhauer, Wadim Weber, Philipp Kemp, Carolin Gebhardt, Marwan Kaufmann, Noel Tewes, Hanna Zhdanova, Alesia Tietze, Oliver Rauh, Viktor Stein: Scaling the Functional Nanopore (FuN) Screen: Systematic Evaluation of Self-Assembling Membrane Peptides and Extension with a K+-Responsive Fluorescent Protein Sensor.
doi:10.1021/acssynbio.3c00671 PMID BibTeX | RIS

2023

Anja J. Engel, Steffen Paech, Markus Langhans, James L. van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh: Combination of hydrophobicity and codon usage bias determines sorting of model K+ channel protein to either mitochondria or endoplasmic reticulum.
doi:10.1111/tra.12915 PMID BibTeX | RIS

Jan H. Krumbach, Daniel Bauer, Atiyeh Sadat Sharifzadeh, Andrea Saponaro, Rene Lautenschläger, Kristina Lange, Oliver Rauh, Dario DiFrancesco, Anna Moroni, Gerhard Thiel, Kay Hamacher: Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block.
doi:10.1085/jgp.202313364 PMID BibTeX | RIS

2021

Timo Smit, Esther Schickel, Omid Azimzadeh, Christine von Toerne, Oliver Rauh, Sylvia Ritter, Marco Durante, Insa S. Schroeder: A Human 3D Cardiomyocyte Risk Model to Study the Cardiotoxic Influence of X-rays and Other Noxae in Adults.
doi:10.3390/cells10102608 PMID BibTeX | RIS

Stefano Conti Nibali, Maria Carmela Di Rosa, Oliver Rauh, Gerhard Thiel, Simona Reina, Vito de Pinto: Cell-free electrophysiology of human VDACs incorporated into nanodiscs: An improved method.
doi:10.1016/j.bpr.2021.100002 PMID BibTeX | RIS

Anja J. Engel, Marina Kithil, Markus Langhans, Oliver Rauh, Matea Cartolano, James L. van Etten, Anna Moroni, Gerhard Thiel: Codon Bias Can Determine Sorting of a Potassium Channel Protein.
doi:10.3390/cells10051128 PMID BibTeX | RIS

Laura-Marie Winterstein, Kerri Kukovetz, Ulf-Peter Hansen, Indra Schroeder, James L. van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh: Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function.
doi:10.1085/jgp.202012731 PMID BibTeX | RIS

2020

Kerri Kukovetz, Brigitte Hertel, Christopher R. Schvarcz, Andrea Saponaro, Mirja Manthey, Ulrike Burk, Timo Greiner, Grieg F. Steward, James L. van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh: A Functional K+ Channel from Tetraselmis Virus 1, a Member of the Mimiviridae.
doi:10.3390/v12101107 PMID BibTeX | RIS

Carter R. Murry, Irina V. Agarkova, Jayadri S. Ghosh, Fiona C. Fitzgerald, Roger M. Carlson, Brigitte Hertel, Kerri Kukovetz, Oliver Rauh, Gerhard Thiel, James L. van Etten: Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae.
doi:10.3390/v12060678 PMID BibTeX | RIS

2019

Denise Eckert, Tobias Schulze, Julian Stahl, Oliver Rauh, James L. van Etten, Brigitte Hertel, Indra Schroeder, Anna Moroni, Gerhard Thiel: A small viral potassium ion channel with an inherent inward rectification.
doi:10.1080/19336950.2019.1605813 PMID BibTeX | RIS

2018

O. Rauh, U. P. Hansen, D. D. Scheub, G. Thiel, I. Schroeder: Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K+ channel.
doi:10.1038/s41598-018-28751-w PMID BibTeX | RIS

Laura-Marie Winterstein, Kerri Kukovetz, Oliver Rauh, Daniel L. Turman, Christian Braun, Anna Moroni, Indra Schroeder, Gerhard Thiel: Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers.
doi:10.1085/jgp.201711904 PMID BibTeX | RIS

2017

Oliver Rauh, Ulf-Peter Hansen, Sebastian Mach, Andreas J. W. Hartel, Kenneth L. Shepard, Gerhard Thiel, Indra Schroeder: Extended beta distributions open the access to fast gating in bilayer experiments-assigning the voltage-dependent gating to the selectivity filter.
doi:10.1002/1873-3468.12898 PMID BibTeX | RIS

Andrea Saponaro, Alessandro Porro, Antonio Chaves-Sanjuan, Marco Nardini, Oliver Rauh, Gerhard Thiel, Anna Moroni: Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
doi:10.1105/tpc.17.00375 PMID BibTeX | RIS

Oliver Rauh, Martin Urban, Leonhard M. Henkes, Tobias Winterstein, Timo Greiner, James L. van Etten, Anna Moroni, Stefan M. Kast, Gerhard Thiel, Indra Schroeder: Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K+ Channels.
doi:10.1021/jacs.7b01158 PMID BibTeX | RIS

Patrick Voos, Mehtap Yazar, René Lautenschläger, Oliver Rauh, Anna Moroni, Gerhard Thiel: The small neurotoxin apamin blocks not only small conductance Ca2+ activated K+ channels (SK type) but also the voltage dependent Kv1.3 channel.
doi:10.1007/s00249-016-1196-0 PMID BibTeX | RIS

2015

Ulf-Peter Hansen, Oliver Rauh, Indra Schroeder: A simple recipe for setting up the flux equations of cyclic and linear reaction schemes of ion transport with a high number of states: The arrow scheme.
doi:10.1080/19336950.2015.1120391 PMID BibTeX | RIS

2014

Fenja Siotto, Corinna Martin, Oliver Rauh, James L. van Etten, Indra Schroeder, Anna Moroni, Gerhard Thiel: Viruses infecting marine picoplancton encode functional potassium ion channels.
doi:10.1016/j.virol.2014.05.002 PMID BibTeX | RIS