Department of Natural Sciences

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Prof. Dr Angelika Muscate-Magnussen

Professor for Instrumental Analysis and Forensics

angelika.muscate-magnussen@h-brs.de

Unit

Department of Natural Sciences

Location

Rheinbach

Room

I 203

Address

von-Liebig-Str. 20

53359, Rheinbach

Telephone

+49 2241 865 583

Profile

Lehrveranstaltungen / Courses
  • Instrumental Analysis
  • Proteomics
  • Biochemistry
  • Forensics
Forschungsgebiete / Research Interests
  • Miniaturized separation methods for complex biological samples
  • High throughput proteomics applications

Publications

Veröffentlichungen /Publications

"9-(5',6'-Dideoxy-β-D-ribo-hex-5'-ynofuranosyl)adenine, a Novel Irreversible Inhibitor of S-Adeno­syl­homocysteine Hydrolase", Ronald J. Parry, Angelika Muscate und Leslie J. Askonas, Biochem., 1991, 30, 9988-97.

 

"Enzyme Inhibitors", Angelika Muscate, Cynthia L. Levinson und George L. Kenyon, Kirk-Othmer Encyclopedia of Chemical Technology, 4. Edition, Mary Howe-Grant (Herausgeber), John Wiley & Sons, Inc., New York, 1994, Vol. 9, 646-671.

 

"Approaches to the Rational Design of Enzyme Inhibitors", Angelika Muscate und George L. Kenyon, Burger's Medicinal Chemistry and Drug Discovery, 5. Edition, John Wiley & Sons, New York, Manfred E. Wolff (Herausgeber), 1995, Vol. 1: Principles and Practice, 733-782 .

 

"Comparison of the Inhibition of Type A and Type B S-Adenosylhomocysteine Hydrolase: Effects of Co­factor Content on Inhibition Behavior and Nucleoside Binding", Ronald J. Parry, Angelika Muscate und Larry W. Hertel, J. Enz. Inh., 1995, 243-53.

 

"Purification and Crystallization of Benzoylformate Decarboxylase", Miriam S. Hasson, Angelika Mus­cate, Gary T. M. Henehan, Peter F. Guidinger, Gregory A. Petsko, Dagmar Ringe und George L. Kenyon, Protein Sci., 1995, 4, 955-9.

 

"Synthesis, Characterization and Inhibitory Activities of Nucleoside ,β-Imido Triphosphate Analogues on Human Immunodeficiency Virus-1 Reverse Transcriptase", Rongshi Li, Angelika Muscate und George L. Kenyon, Bioorg. Chem.,1996, 24(3), 251-261.

 

"The Crystal Structure of Benzoylformate Decarboxylase", Miriam S. Hasson, Angelika Muscate, George L. Kenyon, Gregory A. Petsko und Dagmar Ringe, Biochemistry and Physiologie of Thiamin Diphosphate Enzymes, Intermann, Prien, H. Biswanger und A. Schellenberger (Herausgeber), 1996, 174-176.

 

"Analysis of Oligonucleotides and Antisense DNA Analogs", Aran Paulus, Gerardus Bruin, Iris Barmé, Angelika Muscate und Markus Ehrat, Analysis of Nucleic Acids by Capillary Electrophoresis, Vieweg, Christoph Heller (Herausgeber), 1997, PART III, 313 pp.

 

"The Crystal Structure of Benzoylformate Decarboxylase at 1.6 Angstrom Resolution - Diversity of Catalytic Residues in Thiamin Diphosphate-dependent Enzymes ", Miriam S. Hasson, Angelika Mus­cate, Michael J. Mcleish, Lena S. Polovnikova, John A. Gerlt, George L. Kenyon, Gregory A. Petsko und Dagmar Ringe, Biochem., 1998, 37(28), 9918-9930.

 

"Capillary Affinity Gel Electrophoresis for Combined Size- and Sequence-dependent Separation of Oligonucleotides", Angelika Muscate, Franςois Natt, Aran Paulus, Markus Ehrat, Anal. Chem., 1998, 70(7), 1419-1424.

 

"Enzyme Inhibitors", Angelika Mus­cate, Cynthia L. Levinson und George L. Kenyon, Concise Encyclopedia of Chemical Technology, 4. Edition, Wiley-Interscience, New York, Mary Howe-Grant und Jacqueline I. Kroschwitz (Herausgeber), 1999, 753-754.

 

"Immunoaffinity Screening with Capillary Electrochromatography", Michael Mayer, Angelika Muscate-Magnussen, Horst Vogel, Markus Ehrat und Gerardus JM. Bruin, Electrophoresis, 2002, 23(9), 1255-1262.

 

"A Novel Mechanism for Inhibition of HIV-1 Reverse Transcriptase" Skillman, A.G., Maurer, K.W., Roe, D.C., Stauber, M.J., Eargle, D., Ewing, T.J.A., Muscate, A., Davioud-Charvet, E., Medaglia, M.V., Fisher, R.J., Arnold, E., Gao, H.-Q., Buckheit, R., Boyer, P.L., Hughes, S.H., Kuntz, I.D., and Kenyon, G.L., Bioorg. Chem., 2002, 30 (6), 443-458.

 

Patente/-Anmeldungen

"Naphthols useful in Antiviral Methods", George L. Kenyon, Margaret Stauber, Karl Maurer, Dolan Eargle, Angelika Muscate, Andrew Leavitt, Diana C. Roe, Todd Ewing, Allan Skillman, Edward Arnold, Irwin Kuntz, Malin Young, US Patent Nr. 6,140,368, 2000.

 

"Process for Separating Mixtures of Substances using Capillary Affinity Gel Electrophoresis", Angelika Muscate, Aran Paulus, Franςois Natt, EP0901623, WO9745721, 1999.

 

"Verwendung von Trägermaterial in der Kapillar-Elektrochromatographie", Angelika Muscate-Magnussen, EP1155315, WO0050887, 2001.

 

"Facile Plug-on Devices for Open and Bead Packed Capillaries", Angelika Muscate-Magnussen, Dagmar Weber, EP1255986, WO161338, 2002.