Immunology

Compulsory Course

  • in BSc Applied Biology, 4th Semester 
  • 6h/week (2L/2E/2P)
  • Credits: 7 ECTS

→Download scripts, group assignment etc. (LEA)

Hochschule Bonn-Rhein-Sieg

Lecture

Learning outcomes:

At the end of the study unit lecture/exercise the students are able:

  • to explain the origin of immunological cells from the bone marrow and thymus
  • to understand differentiation and activation of immunological cells
  • to understand the reaction of the immune system to infections

Content:

  • Basics of the immune system; knowledge of immunological techniques: Components of the immune system, immunological organs, structure and function of organs, cells of the immune system
  • Innate immune systeme:Protective function of skin and mucosal tissues, phagocytes, complement system, natural killer cells, cytokines, chemokines, inflammatory reaction
  • Adaptive immunsystem: B-cell system, ´receptors, antigen recognition, antibody production, functions of antibodies;
  • T-cell-system: receptors, antigen recognition, effetor cells, mechanisms of cellular immunity; immunological memory. signal transduktion in the immune system

Exercise

The exercise serves to discuss the content of the lecture based on questions.

Both have the same content.

Practical Course

Learning outcomes:

At the end of the practical course the students are able:

  • to work with blood cells and analyze these in blood smear
  • to apply FACS technology towards the allergen specific degranulation of basophils
  • to sort lymphocyte subsets via magnetic cell sorting
  • to isolate immune cells from different organs and analyze them
  • to test blood groups

Content:

  • Magnetic sorting of cells
  • Degranulation of Basophils with allergens
  • Determination of blood groups, blood picture
  • Flow cytometry
  • Isolation of primary lymphocytes
  • Determination of blood groups

Prerequisites

none

Recommendations: Biology 1-4; Biochemistry

Assessment

Passing of module – graded

The total grade of the module is comprised of:

  1. a written exam about the content of the lecture and the practical course, which has to be passed with at least 50% of the total points. The grade of the exam contributes by 70% to the total grade of the module
  2. writing an individual laboratory report. Grading of the lab report contributes by 30% to the total grade of the module

Literature

  • Immunobiology. C.A. Janeway, P. Travers, M. Walport and J.D. Capra, latest edition