Department of Natural Sciences
STRUCTURAL BIOLOGY
Lecture
Compulsory Course
- In BSc Applied Biology, 5th Semester
- 6h/week (2L/2E/2P)
- Credits: 7 ECTS
Learning outcomes:
Completing this course will allow students to:
- Understand aspects of protein structure and function, structural changes (misfolding) in the context of diseases, and molecular recognition
- Define the assets and drawbacks of different structural biology techniques as well as the advantage of combining structural biology methods
- Make use of the full extent of the protein database (PDB), and to determine and interpret the quality of the provided structural data
Content:
- Fundamentals of Structural Biology
- Protein Structure and Architecture
- Protein Data Bank (PDB)
- X-ray Diffraction
- Protein Crystallization
- Cryo-Electron Microscopy
- Negative Stain Analysis
- X-ray Free Electron Lasers
- Structure-based Drug Development
- Molecular Docking
- Structural Dynamics and Simulations
Internship
Learning outcomes:
- Plan and apply different crystallization techniques
- Processing structural data and building structural models
Content:
- Crystallizing proteins and monitoring crystal growth
- Solving the three-dimensional structure using X-ray crystallography
Requirements
none
- Written exam (100 %)
- Lab report (required to pass the course)
Literature
- B. Rupp, Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology, 1st edition, Garland Science, 2009.
- G. Rhodes, Crystallography Made Crystal Clear: A Guide for Users of Macromolecular Models, 3rd edition, Academic Press, 2006.
- F. Lottspeich, Bioanalytics: Analytical Methods and Concepts in Biochemistry and Molecular Biology, 1st edition, Wiley, 2018.
- D. Klostermeier, Biophysical Chemistry, 1st edition, CRC Press, 2017.
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Location
Rheinbach
Room
E004
Address
von-Liebig-Straße 20
53359, Rheinbach
Telephone
+49 2241 865 9851Location
Rheinbach
Address
von-Liebig-Str. 20
53359, Rheinbach
Location
Rheinbach
Room
F 007.1
Address
von-Liebig-Str. 20
53359, Rheinbach
Telephone
+49 2241 865 567Links
Further links