STRUCTURAL BIOLOGY

Compulsory Course

• In BSc Applied Biology, 5^th Semester
• 6h/week (2L/2E/2P)
• Credits: 7 ECTS

Learning outcomes:

Completing this course will allow students to:

• Understand aspects of protein structure and function, structural changes (misfolding) in the context of diseases, and molecular recognition
• Define the assets and drawbacks of different structural biology techniques as well as the advantage of combining structural biology methods
• Make use of the full extent of the protein database (PDB), and to determine and interpret the quality of the provided structural data

Content:

• Fundamentals of Structural Biology
• Protein Structure and Architecture
• Protein Data Bank (PDB)
• X-ray Diffraction
• Protein Crystallization
• Cryo-Electron Microscopy
• Negative Stain Analysis
• X-ray Free Electron Lasers
• Structure-based Drug Development
• Molecular Docking
• Structural Dynamics and Simulations