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Department of Natural Sciences

althaus_mike_portraet_2020.jpeg (DE)

Prof. Dr Mike Althaus

Professor in Biology, particularly Physiology and Neurobiology


Department of Natural Sciences, Institute for Functional Gene Analytics (IFGA)

Research fields

  • Molecular physiology of ion channels and transporters
  • Epithelial ion transport
  • Regulation of the salt balance
  • Comparative physiology and evolution of ion channels






von-Liebig-Straße 20

53359, Rheinbach


02241 865 9541


Research Fields

  • Molecular Physiology of Ion Channels and Transporters
  • Epithelial Ion Transport
  • Regulation of Salt Homeostasis
  • Comparative Physiology and Ion Channel Evolution



  • Electrophysiological Characterisation of Ion Channels and Transporters (Two-Electrode Voltage-Clamp, Patch-Clamp)
  • Recording of Transepithelial Ion Transport (Ussing-Chambers)
  • Heterologous Expression of Ion Channels and Transporters in Xenopus Oocytes
  • Molecular Biology, Proteinbiochemistry and Cell Culture Techniques




Curriculum vitae

Since 2020 Professor in Biology, particularly Physiology and Neurobiology

2017 - 2020 Lecturer in Animal Physiology, Newcastle University, United Kingdom

2016 - 2017 Researcher, Institute for Anatomy and Cell Biology, Saarland Univeristy, Homburg

2015 - 2016 Interim-Professor in Animal Physiology, Justus-Liebig-University, Giessen

2015 Habilitation in Animal Physiology, Justus-Liebig-University, Giessen

2010 - 2015 PostDoc, Institute for Animal Physiology, Justus-Liebig-University, Giessen

2006 - 2010 Doctorate (Dr. rer. nat.), Institute for Animal Physiology, Justus-Liebig-University, Giessen

2001 - 2006 Studies in Biology, Justus-Liebig-University, Giessen

Research Projects

Analysis platform for molecular mechanisms and cellular functions

An analysis platform consisting of four components offers a significant expansion of biomedical analysis possibilities at Hochschule Bonn-Rhein-Sieg (H-BRS). A binding analysis device based on microscaled thermophoresis contributes an innovative approach to characterising interactions involving proteins. A multi-mode detection device for UV/Vis, fluorescence and luminescence allows, among other things, a variety of enzyme activity tests and imaging studies in new or improved form. An automated patch clamp system and a system for solid-supported membrane (SSM)-based electrophysiology for high-resolution transporter studies provide the equipment basis for expanding research into membrane transport processes and other molecular mechanisms of disease development.

Project management at the H-BRS

Prof. Dr Jörn Oliver Sass


Prof. Dr. Mike Althaus

2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007


Alexander Perniss, Brett Boonen, Sarah Tonack, Moritz Thiel, Krupali Poharkar, Mohamad Wessam Alnouri, Maryam Keshavarz, Tamara Papadakis, Silke Wiegand, Uwe Pfeil, Katrin Richter, Mike Althaus, Johannes Oberwinkler, Burkhard Schütz, Ulrich Boehm, Stefan Offermanns, Trese Leinders-Zufall, Frank Zufall, Wolfgang Kummer: A succinate/SUCNR1-brush cell defense program in the tracheal epithelium.
PDF Download (CC BY 4.0) doi:10.1126/sciadv.adg8842 PMID urn:nbn:de:hbz:1044-opus-74794 BibTeX | RIS

Rene Y. Lawong, Fabian May, Etang C. Etang, Philipp Vorrat, Jonas George, Julia Weder, Dagmar Kockler, Matthias Preller, Mike Althaus: Recording Sodium Self-Inhibition of Epithelial Sodium Channels Using Automated Electrophysiology in Xenopus Oocytes.
PDF Download (CC BY 4.0) doi:10.3390/membranes13050529 urn:nbn:de:hbz:1044-opus-70317 PMID BibTeX | RIS

Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius: ENaC channels.
doi:10.1201/9781003096276-21 BibTeX | RIS

Stephan Maxeiner, Gabriela Krasteva-Christ, Mike Althaus: Pitfalls of using sequence databases for heterologous expression studies - a technical review.
PDF Download (CC BY-NC 4.0) doi:10.1113/JP284066 PMID urn:nbn:de:hbz:1044-opus-67145 BibTeX | RIS

JinHeng Lin, Sean M. Gettings, Khaoula Talbi, Rainer Schreiber, Michael J. Taggart, Matthias Preller, Karl Kunzelmann, Mike Althaus, Michael A. Gray: Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels.
PDF Download (CC BY 4.0) doi:10.1007/s00424-022-02758-9 PMID urn:nbn:de:hbz:1044-opus-64572 BibTeX | RIS


Catriona M. H. Anderson, Noel Edwards, Andrew K. Watson, Mike Althaus, David T. Thwaites: Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives.
PDF Download (CC BY 4.0) doi:10.3390/biom12101404 urn:nbn:de:hbz:1044-opus-64519 PMID BibTeX | RIS

Mike Althaus, Rene Yufenyuy Lawong: Proteolytic ENaC activation in health and disease—a complicated puzzle.
PDF Download (CC BY 4.0) doi:10.1007/s00424-021-02644-w PMID urn:nbn:de:hbz:1044-opus-60084 BibTeX | RIS


Zeshan P. Sheikh, Matthias Wulf, Søren Friis, Mike Althaus, Timothy Lynagh, Stephan A. Pless: The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs.
PDF Download (CC BY-NC-SA 4.0) doi:10.1085/jgp.202112899 PMID urn:nbn:de:hbz:1044-opus-59623 BibTeX | RIS

Sean M. Gettings, Stephan Maxeiner, Maria Tzika, Matthew R. D. Cobain, Irina Ruf, Fritz Benseler, Nils Brose, Gabriela Krasteva-Christ, Greetje Vande Velde, Matthias Schönberger, Mike Althaus: Two Functional Epithelial Sodium Channel Isoforms Are Present in Rodents despite Pronounced Evolutionary Pseudogenization and Exon Fusion.
PDF Download (CC BY 4.0) doi:10.1093/molbev/msab271 PMID urn:nbn:de:hbz:1044-opus-58483 BibTeX | RIS

Iram J. Haq, Mike Althaus, Aaron Ions Gardner, Hui Ying Yeoh, Urjita Joshi, Vinciane Saint-Criq, Bernard Verdon, Jennifer Townshend, Christopher O'Brien, Mahfud Ben-Hamida, Matthew Thomas, Stephen Bourke, Peter van der Sluijs, Ineke Braakman, Chris Ward, Michael A. Gray, Malcolm Brodlie: Clinical and molecular characterization of the R751L-CFTR mutation.
PDF Download (CC BY 4.0) doi:10.1152/ajplung.00137.2020 PMID urn:nbn:de:hbz:1044-opus-52631 BibTeX | RIS


Lukas Wichmann, Mike Althaus: Evolution of epithelial sodium channels: current concepts and hypotheses.
doi:10.1152/ajpregu.00144.2020 PMID BibTeX | RIS


Honglin Feng, Noel Edwards, Catriona M. H. Anderson, Mike Althaus, Rebecca P. Duncan, Yu-Ching Hsu, Charles W. Luetje, Daniel R. G. Price, Alex C. C. Wilson, David T. Thwaites: Trading amino acids at the aphid-Buchnera symbiotic interface.
doi:10.1073/pnas.1906223116 PMID BibTeX | RIS

Lukas Wichmann, Jasdip Singh Dulai, Jon Marles-Wright, Stephan Maxeiner, Pawel Piotr Szczesniak, Ivan Manzini, Mike Althaus: An extracellular acidic cleft confers profound H+-sensitivity to epithelial sodium channels containing the δ-subunit in Xenopus laevispH-sensitivity of Xenopus δ-ENaC.
doi:10.1074/jbc.RA119.008255 PMID BibTeX | RIS

Monika I. Hollenhorst, Innokentij Jurastow, Rajender Nandigama, Silke Appenzeller, Lei Li, Joerg Vogel, Stephanie Wiederhold, Mike Althaus, Martin Empting, Janine Altmueller, Anna K. H. Hirsch, Veit Flockerzi, Brendan J. Canning, Antoine-Emmanuel Saliba, Gabriela Krasteva-Christ: Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.
doi:10.1096/fj.201901314RR PMID BibTeX | RIS


Chrissy Kandel, Patricia Schmidt, Alexander Perniss, Maryam Keshavarz, Paul Scholz, Sabrina Osterloh, Mike Althaus, Wolfgang Kummer, Klaus Deckmann: ENaC in Cholinergic Brush Cells.
doi:10.3389/fcell.2018.00089 PMID BibTeX | RIS

Cassie R. Bakshani, Ana L. Morales-Garcia, Mike Althaus, Matthew D. Wilcox, Jeffrey P. Pearson, John C. Bythell, J. Grant Burgess: Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection.
doi:10.1038/s41522-018-0057-2 PMID BibTeX | RIS

Lukas Wichmann, Kirsty Sophia Vowinkel, Alexander Perniss, Ivan Manzini, Mike Althaus: Incorporation of the -subunit into the epithelial sodium channel (ENaC) generates protease-resistant ENaCs in Xenopus laevis.
doi:10.1074/jbc.RA118.002543 PMID BibTeX | RIS


Anna Zakrzewicz, Katrin Richter, Alisa Agne, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, Veronika Grau: Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1 beta via Different Combinations of Nicotinic Acetylcholine Receptor Subunits alpha 7, alpha 9 and alpha 10.
doi:10.3389/fncel.2017.00189 PMID BibTeX | RIS

Alexander Perniss, Kathrin Preiss, Marcel Nier, Mike Althaus: Hydrogen sulfide stimulates CFTR in Xenopus oocytes by activation of the cAMP/PKA signalling axis.
doi:10.1038/s41598-017-03742-5 PMID BibTeX | RIS

Maryam Keshavarz, Heike Schwarz, Petra Hartmann, Silke Wiegand, Melanie Skill, Mike Althaus, Wolfgang Kummer, Gabriela Krasteva-Christ: Caveolin-1: Functional Insights into Its Role in Muscarine- and Serotonin-Induced Smooth Muscle Constriction in Murine Airways.
doi:10.3389/fphys.2017.00295 PMID BibTeX | RIS


Nicole C. Krause, Hanna S. Kutsche, Fabrizio Santangelo, Eric R. DeLeon, Nikolaus P. Dittrich, Kenneth R. Olson, Mike Althaus: Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorption.
doi:10.1152/ajpregu.00177.2016 PMID BibTeX | RIS

K. Richter, V. Mathes, M. Fronius, M. Althaus, A. Hecker, G. Krasteva-Christ, W. Padberg, A. J. Hone, J. M. McIntosh, A. Zakrzewicz, V. Grau: Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.
doi:10.1038/srep28660 PMID BibTeX | RIS

Ervice Pouokam, Mike Althaus: Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide.
doi:10.1155/2016/4723416 PMID BibTeX | RIS


Alexander Perniss, Annemarie Wolf, Lukas Wichmann, Matthias Schoenberger, Mike Althaus: Evans Blue is not a suitable inhibitor of the epithelial sodium channel δ-subunit.
doi:10.1016/j.bbrc.2015.09.052 PMID BibTeX | RIS

Alisa M. Agne, Jan-Peter Baldin, Audra R. Benjamin, Maria C. Orogo-Wenn, Lukas Wichmann, Kenneth R. Olson, Dafydd V. Walters, Mike Althaus: Hydrogen sulfide decreases β-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption.
doi:10.1152/ajpregu.00489.2014 PMID BibTeX | RIS


Matthias Schoenberger, Mike Althaus, Martin Fronius, Wolfgang Clauss, Dirk Trauner: Controlling epithelial sodium channels with light using photoswitchable amilorides.
doi:10.1038/nchem.2004 PMID BibTeX | RIS

Alexandra Erb, Mike Althaus: Actions of Hydrogen Sulfide on Sodium Transport Processes across Native Distal Lung Epithelia (Xenopus laevis).
doi:10.1371/journal.pone.0100971 PMID BibTeX | RIS

Klaus Deckmann, Katharina Filipski, Gabriela Krasteva-Christ, Martin Fronius, Mike Althaus, Amir Rafiq, Tamara Papadakis, Liane Renno, Innokentij Jurastow, Lars Wessels, Miriam Wolff, Burkhard Schuetz, Eberhard Weihe, Vladimir Chubanov, Thomas Gudermann, Jochen Klein, Thomas Bschleipfer, Wolfgang Kummer: Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.
doi:10.1073/pnas.1402436111 PMID BibTeX | RIS

Anna Bell, Mike Althaus, Martin Diener: Communication between mast cells and rat submucosal neurons.
doi:10.1007/s00424-014-1609-9 PMID BibTeX | RIS


Matthias Schoenberger, Mike Althaus: Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation.
doi:10.1517/13543776.2013.829454 PMID BibTeX | RIS

Mike Althaus, Wolfgang G. Clauss: Gasotransmitters: novel regulators of ion channels and transporters.
doi:10.3389/fphys.2013.00027 PMID BibTeX | RIS

Mike Althaus: ENaC inhibitors and airway re-hydration in cystic fibrosis: state of the art.
doi:10.2174/18744672112059990025 PMID BibTeX | RIS


Patrick Krumm, Teresa Giraldez, Diego Alvarez de la Rosa, Wolfgang G. Clauss, Martin Fronius, Mike Althaus: Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC).
doi:10.1016/j.bmc.2012.05.021 PMID BibTeX | RIS

Martin Fronius, Wolfgang G. Clauss, Mike Althaus: Why do we have to move fluid to be able to breathe?.
doi:10.3389/fphys.2012.00146 PMID BibTeX | RIS

Mike Althaus: Gasotransmitters: novel regulators of epithelial Na+ transport?.
doi:10.3389/fphys.2012.00083 PMID BibTeX | RIS

Diana Wesch, Mike Althaus, Pablo Miranda, Ignacio Cruz-Muros, Martin Fronius, Tomas Gonzalez-Hernandez, Wolfgang G. Clauss, Diego Alvarez de la Rosa, Teresa Giraldez: Differential N termini in epithelial Na+ channel δ-subunit isoforms modulate channel trafficking to the membrane.
doi:10.1152/ajpcell.00255.2011 PMID BibTeX | RIS

M. Althaus, K. D. Urness, W. G. Clauss, D. L. Baines, M. Fronius: The gasotransmitter hydrogen sulphide decreases Na⁺ transport across pulmonary epithelial cells.
doi:10.1111/j.1476-5381.2012.01909.x PMID BibTeX | RIS


Mike Althaus, Alexandra Pichl, Wolfgang G. Clauss, Werner Seeger, Martin Fronius, Rory E. Morty: Nitric Oxide Inhibits Highly Selective Sodium Channels and the Na+/K+-ATPase in H441 Cells.
doi:10.1165/2009-0335OC PMID BibTeX | RIS

Mike Althaus, Wolfgang G. Clauss, Martin Fronius: Amiloride-sensitive sodium channels and pulmonary edema.
doi:10.1155/2011/830320 PMID BibTeX | RIS


Diana Wesch, Pablo Miranda, Domingo Afonso-Oramas, Mike Althaus, Javier Castro-Hernandez, Jaime Dominguez, Rory E. Morty, Wolfgang Clauss, Tomas Gonzalez-Hernandez, Diego Alvarez de la Rosa, Teresa Giraldez: The neuronal-specific SGK1.1 kinase regulates δ-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling.
doi:10.1152/ajpcell.00184.2010 PMID BibTeX | RIS

Martin Fronius, Roman Bogdan, Mike Althaus, Rory E. Morty, Wolfgang G. Clauss: Epithelial Na+ channels derived from human lung are activated by shear force.
doi:10.1016/j.resp.2009.11.004 PMID BibTeX | RIS


Mike Althaus, Martin Fronius, Yasmin Buchaeckert, Istvan Vadasz, Wolfgang G. Clauss, Werner Seeger, Roberto Motterlini, Rory E. Morty: Carbon Monoxide Rapidly Impairs Alveolar Fluid Clearance by Inhibiting Epithelial Sodium Channels.
doi:10.1165/rcmb.2008-0458OC PMID BibTeX | RIS


Mike Althaus, Roman Bogdan, Wolfgang G. Clauss, Martin Fronius: Mechano-sensitivity of epithelial sodium channels (ENaCs): laminar shear stress increases ion channel open probability.
doi:10.1096/fj.06-7694com PMID BibTeX | RIS