Department of Natural Sciences
Unit
Department of Natural Sciences, Institute for Functional Gene Analytics (IFGA)
Research fields
- Modelling/simulation of nicotinic acetylcholine receptors
Location
Rheinbach
Room
E106
Address
Von-Liebig-Str. 20
53359 Rheinbach
Telephone
+49 2241 865 9255Profile
PhD Research Topic
The aim of my study is to investigate the binding mechanisms of modulators to nicotinic acetylcholine receptors (nAChRs) through molecular modeling and computational simulation techniques. This research focuses on understanding how modulators interact with nAChRs that have varying subunit assemblies, providing insights into their structural and functional dynamics.
Curriculum vitae
06/2023 – 02/2024 Student research assistant, Chemo informatics, Computational Medicinal Chemistry & Chemical Biology in Bajorath's lab, University of Bonn
01/2021 – 12/2021 Clinical Pharmacist, Portsaid Hospital, Egypt
05/2020 - 07/2020 Research Intern, Clinical Pharmacy Training Program, Zagazig University Hospital, Egypt
Research Projects
The German Research Foundation funded research cluster "CytoTransport" combines expertise in biomedicine, computational modelling, structural biology, chemistry and materials science to investigate cellular transport mechanisms in health and disease. To this end, 9 working groups from two university research focuses are working together, represented by the two research institutes IFGA and TREE. An overarching goal is to bundle the institutes' overlapping interests and expertise in the long term.
Project management at the H-BRS
Prof. Dr Mike Althaus Dr Karl Kirschner Prof. Dr Matthias Preller Prof. Dr Dirk Reith Prof. Dr Jörn Oliver Sass Prof. Dr Margit Schulze Prof. Dr Christopher Volk Prof. Dr Steffen Witzleben Dr Katrin Richter
Publications
Mona Mobasher
2026
Mona Mobasher, Arik J. Hone, Malin Pilzecker, Daria Bozic, Andreas Hecker, J. Michael McIntosh, Karl N. Kirschner, Veronika Grau, Roger L. Papke, Hina Andleeb, Katrin Richter:
Putative α7-selective ligands interact with α9-containing nicotinic acetylcholine receptors and modulate immune functions of human mononuclear phagocytes.
PDF Download (CC BY 4.0) doi:10.3389/fimmu.2026.1773637 urn:nbn:de:hbz:1044-opus-94807 PMID
BibTeX | RIS
2024
Mona Mobasher, Martin Vogt, Elena Xerxa, Jürgen Bajorath:
Comprehensive Data-Driven Assessment of Non-Kinase Targets of Inhibitors of the Human Kinome.
doi:10.3390/biom14030258 PMID
BibTeX | RIS