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Institute for Functional Gene Analytics (IFGA)

fb05_bild_martin_sieber_2018 (DE)

Prof. Dr Martin Sieber

Professor for Clinical Research


Institute for Functional Gene Analytics (IFGA)




I 220


von-Liebig-Straße 20

53359, Rheinbach


+49 2241 865 533



1. Clinical Operations:

Current Studies:

  • GPNMB serum level in patients with acute coronary syndrome: a exploratory study (ProKoro1); DRKS# 00022900 (Helios Klinikum Emil von Behring & Max-Delbrück Centrum, Berlin)

  • Exploratory  „Proof of concept“ Study regarding the safety and usability of a pneumatic knee device (pneuMO1) DRKS# 0002411. (Institut Prof. Kurscheid, Cologne)

  • Market Reserach maremed® MK 500 (Beurer GmbH, Ulm & Institut Prof. Kurscheid, Cologne)

2. Mirkobiome Research

Selection Supervised Theses:
  • Evaluation of Telecardiologic Systems for QTc Diagnostic: Lena-Sophie Fink, M.Sc.
  • Implementation of the New Medical Device Regulation: Consequences for CliniMACS Cell Separation System. Victoria Kneissler, M.Sc.
  • IoR Remote Medical Monitoring for Heart Patients: Ashley Sekulich, M.Sc.
  • Key clinical development figures and machine learning: Harald Rößels, B.Sc.
  • The Clinical Research Nurse Perspective on Clinical Trials: Mhairi Sharkey, B.Sc.



Curriculum vitae

Professor for Clinical Research, University Bonn-Rhein-Sieg

Senior Global Clinical Project Manager: Global Clinical Development Bayer Pharma AG

Global Medical Affairs Scientist, Global Medical Affairs Excellence and Operations Bayer Pharma AG

Global Medical Affairs Manager, Global Development, Intendis GmbH

Global Medical Marketing Manager, Global Strategic Marketing, Intendis GmbH

Laborleiter, Drug Discovery, Bayer Schering Pharma AG, Berlin

Ph.D. Freie Universität Berlin / Max-Delbrück-Centrum für Molekulare Medizin 

Study of  Biology  at the Friedrich Wilhelm University Bonn


Research Projects

LowGHGWatt - Reduction of greenhouse gases in water treatment through integrated technologies against biofouling

LowGHGWatt is a joint project with the Israeli Ben-Gurion University of the Negev. It is funded within the framework of the German-Israeli Water Technology Cooperation by BMBF and MOST.

Project management at the H-BRS

Prof. Dr Steffen Witzleben


Publications in “Peer Review” Journals:

  1. Jost G, Lenhard DC, Sieber MA, Lohrke J, Frenzel T, Pietsch H.Signal Increase on Unenhanced T1-Weighted Images in the Rat Brain After Repeated, Extended Doses of Gadolinium-Based Contrast Agents: Comparison of Linear and Macrocyclic Agents. Invest Radiol. 2016 Feb;51(2):83-9.

  2. Czaika VA, Siebenbrock J, Czekalla F, Zuberbier T, Sieber MAReactive oxygen species and the bacteriostatic and bactericidal effects of isoconazole nitrate. Mycoses. 2013 May;56 Suppl 1:16-22.

  3. Lenhard DC, Pietsch H, Sieber MA, Ernst R, Lengsfeld P, Ellinghaus P, Jost G. The osmolality of nonionic, iodinated contrast agents as an important factor for renal safety. Invest Radiol. 2012 Sep;47(9):503-10.

  4. Jost G, Lenhard DC, Sieber MA, Lengsfeld P, Hutter J, Pietsch H. Changes of Renal Water Diffusion Coefficient After Application of Iodinated Contrast Agents: Effect of Viscosity. Invest Radiol. 2011 Dec;46(12):796-800.

  5. Pietsch H, Raschke M, Ellinger-Ziegelbauer H, Jost G, Walter J, Frenzel T, Sieber MAThe role of residual gadolinium in the induction of nephrogenic systemic fibrosis-like skin lesions in rats. Invest Radiol 2011;46(1):48-56.

  6. Jost G, Lengsfeld P, Lenhard DC, Pietsch H, Hutter J, Sieber MAViscosity of iodinated contrast agents during renal excretion. Eur J Radiol. 2011 Nov;80(2):373-7 .

  7. Steger-Hartmann T, Hofmeister R, Ernst R, Pietsch H, Sieber MA, Walter J. A review of preclinical safety data for magnevist (gadopentetate dimeglumine) in the context of nephrogenic systemic fibrosis. Invest Radiol 2010;45(9):520-8.

  8. Jost G, Pietsch H, Lengsfeld P, Hutter J, Sieber MAThe impact of the viscosity and osmolality of iodine contrast agents on renal elimination. Invest Radiol 2010;45(5):255-61.

  9. Behrendt FF, Pietsch H, Jost G, Sieber MA, Keil S, Plumhans C, Seidensticker P, Gunther RW, Mahnken AH. Intra-individual comparison of different contrast media concentrations (300 mg, 370 mg and 400 mg iodine) in MDCT. Eur Radiol 2010;20(7):1644- 50.

  10. Storm R, Cholewa-Waclaw J, Reuter K, Brohl D, Sieber M, Treier M, Muller T, Birchmeier C. The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei. Development 2009;136(2):295-305.

  11. Steger-Hartmann T, Raschke M, Riefke B, Pietsch H, Sieber MA, Walter J. The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - a mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide. Exp Toxicol Pathol 2009;61(6):537-52.

  12. Pietsch H, Pering C, Lengsfeld P, Walter J, Steger-Hartmann T, Golfier S, Frenzel T, Hutter J, Weinmann HJ, Sieber MAEvaluating the role of zinc in the occurrence of fibrosis of the skin: a preclinical study. J Magn Reson Imaging 2009;30(2):374-83.

  13. Pietsch H, Lengsfeld P, Steger-Hartmann T, Lowe A, Frenzel T, Hutter J, Sieber MAImpact of renal impairment on long-term retention of gadolinium in the rodent skin following the administration of gadolinium-based contrast agents. Invest Radiol 2009;44(4):226-33.

  14. Pietsch H, Lengsfeld P, Jost G, Frenzel T, Hutter J, Sieber MALong-term retention of gadolinium in the skin of rodents following the administration of gadolinium-based contrast agents. Eur Radiol 2009;19(6):1417-24

  15. Pietsch H, Jost G, Frenzel T, Raschke M, Walter J, Schirmer H, Hutter J, Sieber MAEfficacy and safety of lanthanoids as X-ray contrast agents. Eur J Radiol 2009.

  16. Mahnken AH, Jost G, Bruners P, Sieber M, Seidensticker PR, Gunther RW, Pietsch H. Multidetector computed tomography (MDCT) evaluation of myocardial viability: intraindividual comparison of monomeric vs. dimeric contrast media in a rabbit model. Eur Radiol 2009;19(2):290-7.

  17. Jost G, Pietsch H, Sommer J, Sandner P, Lengsfeld P, Seidensticker P, Lehr S, Hutter J, Sieber MARetention of iodine and expression of biomarkers for renal damage in the kidney after application of iodinated contrast media in rats. Invest Radiol 2009;44(2):114-23.

  18. Sieber MA, Lengsfeld P, Walter J, Schirmer H, Frenzel T, Siegmund F, Weinmann HJ, Pietsch H. Gadolinium-based contrast agents and their potential role in the pathogenesis of nephrogenic systemic fibrosis: the role of excess ligand. J Magn Reson Imaging 2008;27(5):955-62.

  19. Sieber MA, Lengsfeld P, Frenzel T, Golfier S, Schmitt-Willich H, Siegmund F, Walter J, Weinmann HJ, Pietsch H. Preclinical investigation to compare different gadolinium-based contrast agents regarding their propensity to release gadolinium in vivo and to trigger nephrogenic systemic fibrosis-like lesions. Eur Radiol 2008;18(10):2164-73.

  20. Sieber MA*, Pietsch H*, Walter J, Haider W, Frenzel T, Weinmann HJ. A preclinical study to investigate the development of nephrogenic systemic fibrosis: a possible role for gadolinium-based contrast media. Invest Radiol 2008;43(1):65-75.

  21. Sieber MA*, Storm R*, Martinez-de-la-Torre M, Muller T, Wende H, Reuter K, Vasyutina E, Birchmeier C. Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain. J Neurosci 2007;27(18):4902-9. *Autoren habe zu gleichen Teilen beigetragen


Review Articles in “Peer Review” Journals

  1. Frenzel T, Lawaczeck R, Taupitz M, Jost G, Lohrke J, Sieber MA, Pietsch H. Contrast Media for X-ray and Magnetic Resonance Imaging: Development, Current Status and Future Perspectives. Invest Radiol. 2015 Sep;50(9):671-8.

  2. Sieber MA, Hegel JK. Azelaic acid: Properties and mode of action. Skin Pharmacol Physiol. 2014;27 Suppl 1:9-17.

  3. Sieber MA, Steger-Hartmann T, Lengsfeld P, Pietsch H. Gadolinium-based contrast agents and NSF: evidence from animal experience. J Magn Reson Imaging 2009;30(6):1268-76.

Book Chapers and other Publications:

  1. Sieber MA, Pietsch H, Michaely, H, Nephrogene Systemische Fibrose (NSF) In: MR-Angiographie Editor Stefan O. Schönberg, Springer Berlin Heidelberg; ISBN-10: 3642105270

  2. Jan Endrikat, J, Sieber MA, Acris J, Pietsch H, Letter To the Editor: Tissue gadolinium deposition in hepatorenally impaired rats exposed to Gd‑EOB‑DTPA La Radiologia medica submitted 2015

  3. Sieber MA; Pharmaceutical and safety aspects of Gadolinium-based contrast agents EJHP Practice 2009; 15 (6)24-26

  4. Sieber MA, Lengsfeld P, Pietsch H. Response to editor: animal models for nephrogenic systemic fibrosis. Acta Radiol 2008;49(8):963-4.