Genetic information contained in the DNA sequence is the fundamental basis of all physiological processes. Some inherited or acquired DNA sequence variants alter the genetic information and can thus impair the function of the gene products and ultimately lead to diseases. The identification of such DNA variants is therefore crucial for an improved understanding of diseases. The Institute for Functional Gene Analysis uses modern high-throughput sequencing methods (NGS) for this purpose. The Institute aims to identify DNA variants by means of NGS and clarifying their functional consequences at the molecular and cellular level level.