Prof. Dr Richard Jäger

Sarah Aurora Heß, Jan-Philip Biermann, Melanie Grabmüller, Burkhard Madea, Ralf Thiele, Richard Jäger: Evaluation of STR profiles of single telogen hairs using probabilistic methods. In: Forensic Science International: Genetics Supplement Series, 7(1), 2019, S. 454-456
doi:10.1016/j.fsigss.2019.10.049 BibTeX | RIS

Eoghan McGrath, Susan Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne Gorman, Afshin Samali: The Unfolded Protein Response in Breast Cancer. In: Cancers, 10(10), 2018, S. 344
PDF Download doi:10.3390/cancers10100344 urn:nbn:de:hbz:1044-opus-40650 BibTeX | RIS

Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali: Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. In: Nature Communications, Vol.9, 2018, S. 3267
PDF Download doi:10.1038/s41467-018-05763-8 urn:nbn:de:hbz:1044-opus-39907 BibTeX | RIS

Glenn M.G. Theunissen, Burkhard Rolf, Andrew Gibb, Richard Jäger: DNA profiling of sperm cells by using micromanipulation and whole genome amplification. In: Forensic Science International: Genetics Supplement Series, Vol.6, 2017, S. e497-e499
doi:10.1016/j.fsigss.2017.09.183 BibTeX | RIS

Behzad Yeganeh, Richard Jäger, Adrienne M. Gorman, Afshin Samali, Saeid Ghavami: Induction of Autophagy: Role of Endoplasmic Reticulum Stress and Unfolded Protein Response. In: Hayat (Ed.): Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Volume 7: Role of Autophagy in Therapeutic Applications, San Diego, CA: Academic Press, 2015, S. 91-101
doi:10.1016/B978-0-12-801043-3.00005-4 BibTeX | RIS

Donna Kennedy, Afshin Samali, Richard Jäger: Methods for Studying ER Stress and UPR Markers in Human Cells. In: Oslowski (Ed.): Stress responses: Methods and protocols. Methods in Molecular Biology (MIMB), Vol 1292, New York, NY: Humana Press, 2015, S. 3-18
doi:10.1007/978-1-4939-2522-3_1 BibTeX | RIS

Afshin Samali, Richard Jäger: Mechanisms of Resistance to Cell Death Pathways in Cancer Cells. In: McManus, Mitchell (Eds.): Pathobiology of human disease. A dynamic encyclopedia of disease mechanisms, Amsterdam: Academic Press, 2014, S. 393-402
doi:10.1016/B978-0-12-386456-7.01907-9 BibTeX | RIS

Donna Kennedy, Richard Jäger, Dick D. Mosser, Afshin Samali: Regulation of apoptosis by heat shock proteins. In: IUBMB life, 66(5), 2014, S. 327-338
doi:10.1002/iub.1274 BibTeX | RIS

Patrick F. Connolly, Richard Jäger, Howard O. Fearnhead: New roles for old enzymes: killer caspases as the engine of cell behavior changes. In: Frontiers in Physiology, Vol.5, 2014, S. 149
PDF Download doi:10.3389/fphys.2014.00149 urn:nbn:de:hbz:1044-opus-13374 BibTeX | RIS

Lisa Vincenz, Richard Jäger, Michael O'Dwyer, Afshin Samali: Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma. In: Mol Cancer Ther. (Molecular Cancer Therapeutics), 12(6), 2013, S. 831-843
doi:10.1158/1535-7163.MCT-12-0782 BibTeX | RIS

Richard Jäger, Howard O. Fearnhead: Mitochondrial Regulation of Cell-Death. In: Chandra (Ed.): Mitochondria as targets for phytochemicals in cancer prevention and therapy, New York, NY: Springer, 2013, S. 33-60
doi:10.1007/978-1-4614-9326-6_3 BibTeX | RIS

Richard Jäger, Howard O. Fearnhead: "Dead Cells Talking": The Silent Form of Cell Death Is Not so Quiet. In: Biochem Res Int. (Biochemistry Research International), Vol.2012, 2012, S. 453838
PDF Download doi:10.1155/2012/453838 urn:nbn:de:hbz:1044-opus-9505 BibTeX | RIS

Tom Verfaillie, Richard Jäger, Afshin Samali, Patrizia Agostinis: ER Stress Signaling Pathways in Cell Survival and Death. In: Agostinis, Samali (Eds.): Endoplasmic Reticulum Stress in Health and Disease, Dordrecht: Springer, 2012, S. 41-73
doi:10.1007/978-94-007-4351-9_3 BibTeX | RIS

Sandra J. M. Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis, Afshin Samali: Biology of the Endoplasmic Reticulum. In: Agostinis, Samali (Eds.): Endoplasmic Reticulum Stress in Health and Disease, Dordrecht: Springer, 2012, S. 3-22
doi:10.1007/978-94-007-4351-9_1 BibTeX | RIS

Richard Jäger, Mathieu J. M. Bertrand, Adrienne M. Gorman, Peter Vandenabeele, Afshin Samali: The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. In: Biol Cell. (Biology of the Cell), 104(5), 2012, S. 259-270
doi:10.1111/boc.201100055 BibTeX | RIS

Adrienne M. Gorman, Sandra J.M. Healy, Richard Jäger, Afshin Samali: Stress management at the ER: Regulators of ER stress-induced apoptosis. In: Pharmacol Ther. (Pharmacology & Therapeutics), 134(3), 2012, S. 306-316
doi:10.1016/j.pharmthera.2012.02.003 BibTeX | RIS

Lisa Vincenz, Eva Szegezdi, Richard Jäger, Caitriona Holohan, Timothy OBrien, Afshin Samali: Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus. In: Liu (Ed.): Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments, London: InTech, 2011, S. 213-240
doi:10.5772/22765 BibTeX | RIS

Richard Jäger, Ralf M. Zwacka: The enigmatic roles of caspases in tumor development. In: Cancers, 2(4), 2010, S. 1952-1979
doi:10.3390/cancers2041952 BibTeX | RIS

Verena Thewes, Francesca Orso, Richard Jäger, Dawid Eckert, Sabine Schäfer, Gregor Kirfel, Stephan Garbe, Daniela Taverna, Hubert Schorle: Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells. In: BMC Cancer, Vol.10, 2010, S. 192
doi:10.1186/1471-2407-10-192 BibTeX | RIS

Richard Jäger, Sabine Schäfer, Mathilde Hau-Liersch, Hubert Schorle: Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. In: Dev Dyn. (Developmental Dynamics), 239(3), 2010, S. 1027-1033
doi:10.1002/dvdy.22239 BibTeX | RIS

Patricia Kurth, Anne Moenning, Richard Jäger, Gaby Beine, Hubert Schorle: An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system. In: Dev Dyn. (Developmental Dynamics), 238(5), 2009, S. 1064-1072
doi:10.1002/dvdy.21939 BibTeX | RIS

Francesca Orso, Richard Jäger, Raffaele Adolfo Calogero, Hubert Schorle, Piero Sismondi, Michele de Bortoli, Daniela Taverna: AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase. In: BMC Biol. (BMC Biology), Vol.7, 2009, S. 25
doi:10.1186/1741-7007-7-25 BibTeX | RIS

Johannes Schenkel, Hans Weiher, Gerhard Fürstenberger, Richard Jäger: Suprabasal BCL-2 Expression Does Not Sensitize to Chemically-induced Skin Cancer in Transgenic Mice. In: Anticancer Res. (Anticancer Research), 28(5A), 2008, S. 2825-2829
URL BibTeX | RIS

Anne Moenning, Richard Jäger, Angela Egert, Wolfram Kress, Eva Wardelmann, Hubert Schorle: Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. In: Mol Cell Biol. (Molecular and Cellular Biology), 29(3), 2008, S. 881-891
doi:10.1128/MCB.00885-08 BibTeX | RIS

Richard Jäger, Leontios Pappas, Hubert Schorle: Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. In: BMC Res Notes (BMC Research Notes), Vol.1, 2008, S. 29
doi:10.1186/1756-0500-1-29 BibTeX | RIS

Jochen Maurer, Sebastian Fuchs, Richard Jäger, Bodo Kurz, Lukas Sommer, Hubert Schorle: Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. In: Differentiation, 75(7), 2007, S. 580-591
doi:10.1111/j.1432-0436.2007.00164.x BibTeX | RIS

Michael Peitz, Richard Jäger, Christoph Patsch, Andrea Jäger, Angela Egert, Hubert Schorle, Frank Edenhofer: Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells. In: Genesis, 45(8), 2007, S. 508-517
doi:10.1002/dvg.20321 BibTeX | RIS

Richard Jäger: Targeting the death machinery in mammary epithelial cells: Implications for breast cancer from transgenic and tissue culture experiments. In: Crit Rev Oncol Hematol. (Critical Reviews in Oncology/Hematology), 63(3), 2007, S. 231-240
doi:10.1016/j.critrevonc.2007.05.006 BibTeX | RIS

Dawid Eckert, Sandra Buhl, Susanne Weber, Richard Jäger, Hubert Schorle: The AP-2 family of transcription factors. In: Genome Biol. (Genome Biology), 6(13), 2005, S. 246
doi:10.1186/gb-2005-6-13-246 BibTeX | RIS

Richard Jäger, Jens Hahne, Andrea Jacob, Angela Egert, Johannes Schenkel, Nicolas Wernert, Hubert Schorle, Axel Wellmann: Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas. In: Anticancer Res. (Anticancer Research), 25(5), 2005, S. 3191-3196
URL BibTeX | RIS

Richard Jennemann, Roger Sandhoff, Shijun Wang, Eva Kiss, Norbert Gretz, Cecilia Zuliani, Ana Martin-Villalba, Richard Jäger, Hubert Schorle, Marc Kenzelmann, Mahnaz Bonrouhi, Herbert Wiegandt, Hermann-Josef Gröne: Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. In: Proc Natl Acad Sci USA (Proceedings of the National Academy of Sciences of the United States of America), 102(35), 2005, S. 12459-12464
doi:10.1073/pnas.0500893102 BibTeX | RIS

Katharina Pauls, Richard Jäger, Susanne Weber, Eva Wardelmann, Arend Koch, Reinhard Büttner, Hubert Schorle: Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors. In: Int J Cancer (International Journal of Cancer), 115(3), 2005, S. 470-477
doi:10.1002/ijc.20913 BibTeX | RIS

Richard Jäger, Nicolaus Friedrichs, Inge Heim, Reinhard Büttner, Hubert Schorle: Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis. In: Breast Cancer Res Treat. (Breast Cancer Research and Treatment), 90(3), 2005, S. 273-280
doi:10.1007/s10549-004-4815-x BibTeX | RIS

Nicolaus Friedrichs, Richard Jäger, Ellen Paggen, Christian Rudlowski, Sabine Merkelbach-Bruse, Hubert Schorle, Reinhard Buettner: Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. In: Mod Pathol. (Modern Pathology), 18(3), 2004, S. 431-438
doi:10.1038/modpathol.3800292 BibTeX | RIS

Richard Jäger, Jochen Maurer, Andrea Jacob, Hubert Schorle: Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. In: Genesis, 38(3), 2004, S. 145-150
doi:10.1002/gene.20014 BibTeX | RIS

Richard Jäger, Uwe Werling, Stephan Rimpf, Andrea Jacob, Hubert Schorle: Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. In: Mol Cancer Res. (Molecular Cancer Research), 1(12), 2003, S. 921-929
URL BibTeX | RIS

M. D. Lacher, A. Siegenthaler, R. Jäger, Xi Yan, S. Hett, L. Xuan, S. Saurer, R. R. Lareu, A. M. Dharmarajan, R. Friis: Role of DDC-4/sFRP-4, a secreted frizzled-related protein, at the onset of apoptosis in mammary involution. In: Cell Death Differ. (Cell Death and Differentiation), 10(5), 2003, S. 528-538
doi:10.1038/sj.cdd.4401197 BibTeX | RIS

Nadia Munarini, Richard Jäger, Susanne Abderhalden, Gisela Zuercher, Valeria Rohrbach, Saemi Loercher, Brigitte Pfanner-Meyer, Anne-Catherine Andres, Andrew Ziemiecki: Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase. In: J Cell Sci. (Journal of Cell Science), 115(1), 2002, S. 25-37
URL BibTeX | RIS

Andreas Marti, Philipp M. Ritter, Richard Jäger, Hedvika Lazar, Anna Baltzer, Johannes Schenkel, Wim Declercq, Peter Vandenabeele, Rolf Jaggi: Mouse mammary gland involution is associated with cytochrome c release and caspase activation. In: Mech Dev. (Mechanisms of Development), 104(1-2), 2001, S. 89-98
doi:10.1016/S0925-4773(01)00381-1 BibTeX | RIS

Priscilla A. Furth, Ud Bar-Peled, Minglin Li, Albert Lewis, Rodolfo Laucirica, Richard Jäger, Hans Weiher, Robert G. Russell: Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model. In: Oncogene, 18(47), 1999, S. 6589-6596
doi:10.1038/sj.onc.1203073 BibTeX | RIS

Kristen L. Murphy, Frances S. Kittrell, Jason P. Gay, Richard Jäger, Daniel Medina, Jeffrey M. Rosen: Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice. In: Oncogene, 18(47), 1999, S. 6597-6604
doi:10.1038/sj.onc.1203099 BibTeX | RIS

Kristel Schorr, Minglin Li, Ud Bar-Peled, Albert Lewis, Alonso Heredia, Bernadette Lewis, C. Michael Knudson, Stanley J. Korsmeyer, Richard Jäger, Hans Weiher, Priscilla A. Furth: Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. In: Cancer Res. (Cancer research), 59(11), 1999, S. 2541-2545
URL BibTeX | RIS

Richard Jäger, Ute Herzer, Johannes Schenkel, Hans Weiher: Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. In: Oncogene, 15(15), 1997, S. 1787-1795
doi:10.1038/sj.onc.1201353 BibTeX | RIS

Robin C. Humphreys, Maryla Krajewska, Susanne Krnacik, Richard Jäger, Hans Weiher, Stanislaw Krajewski, John C. Reed, Jeffrey M. Rosen: Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. In: Development, 122(12), 1996, S. 4013-4022
URL BibTeX | RIS

Marina Schorpp, Richard Jäger, Karl Schellander, Johannes Schenkel, Erwin F. Wagner, Hans Weiher, Peter Angel: The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. In: Nucleic Acids Res. (Nucleic Acids Research), 24(9), 1996, S. 1787-1788
doi:10.1093/nar/24.9.1787 BibTeX | RIS