Prof. Dr Richard Jäger

Professor for Biology, espec. Forensic Biology

Field of research


  • Forensic DNA Analysis
  • Next Generation Sequencing

previous expertise:

  • ER stress
  • gene targeting/conditional transgenesis
  • mammary gland development and breast cancer
  • apoptosis


Hochschule Bonn-Rhein-Sieg
richard.jaeger [at]


A 274

Curriculum vitae

  • Diploma in Biology (Zoology and Genetics) and Dr. rer nat. at University of Karlsruhe, Germany
  • 1997 Department of Clinical Research, University of Berne, Switzerland
  • 1999 Institute of Toxicology and Genetics, Research Center Karlsruhe, Germany
  • 2002 Institute of Pathology, University Clinic Bonn, Germany
  • 2009 NCBES, Biochemistry, University of Galway, Ireland
  • since 2012: Professor of Biology, Hochschule Bonn-Rhein-Sieg


Prof. Dr. Richard Jäger

2021 | 2019 | 2018 | 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005 | 2004 | 2003 | 2002 | 2001 | 1999 | 1997 | 1996


Richard Jäger, Hans Weiher: DNA Sequencing.
BibTeX | RIS

Richard Jäger, Hans Weiher: Polymerase Chain Reaction.
BibTeX | RIS

Sarah Aurora Heß, Salvatore Trapani, Maria del Mar Boronat, Glenn M. G. Theunissen, Burkhard Rolf, Richard Jäger: Ribosomal DNA as target for the assessment of DNA degradation of human and canine DNA.
doi:10.1016/j.legalmed.2020.101819 PMID BibTeX | RIS


Sarah Aurora Heß, Jan-Philip Biermann, Melanie Grabmüller, Burkhard Madea, Ralf Thiele, Richard Jäger: Evaluation of STR profiles of single telogen hairs using probabilistic methods.
doi:10.1016/j.fsigss.2019.10.049 BibTeX | RIS


Eoghan McGrath, Susan Logue, Katarzyna Mnich, Shane Deegan, Richard Jäger, Adrienne Gorman, Afshin Samali: The Unfolded Protein Response in Breast Cancer.
PDF Download (CC BY 4.0) doi:10.3390/cancers10100344 urn:nbn:de:hbz:1044-opus-40650 PMID BibTeX | RIS

Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali: Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
PDF Download (CC BY 4.0) doi:10.1038/s41467-018-05763-8 PMID urn:nbn:de:hbz:1044-opus-39907 BibTeX | RIS


Glenn M. G. Theunissen, Burkhard Rolf, Andrew Gibb, Richard Jäger: DNA profiling of sperm cells by using micromanipulation and whole genome amplification.
doi:10.1016/j.fsigss.2017.09.183 BibTeX | RIS


Behzad Yeganeh, Richard Jäger, Adrienne M. Gorman, Afshin Samali, Saeid Ghavami: Induction of Autophagy: Role of Endoplasmic Reticulum Stress and Unfolded Protein Response.
doi:10.1016/B978-0-12-801043-3.00005-4 BibTeX | RIS

Donna Kennedy, Afshin Samali, Richard Jäger: Methods for Studying ER Stress and UPR Markers in Human Cells.
doi:10.1007/978-1-4939-2522-3_1 PMID BibTeX | RIS


Afshin Samali, Richard Jäger: Mechanisms of Resistance to Cell Death Pathways in Cancer Cells.
doi:10.1016/B978-0-12-386456-7.01907-9 BibTeX | RIS

Donna Kennedy, Richard Jäger, Dick D. Mosser, Afshin Samali: Regulation of apoptosis by heat shock proteins.
doi:10.1002/iub.1274 PMID BibTeX | RIS

Patrick F. Connolly, Richard Jäger, Howard O. Fearnhead: New roles for old enzymes: killer caspases as the engine of cell behavior changes.
PDF Download (CC BY 3.0) doi:10.3389/fphys.2014.00149 PMID urn:nbn:de:hbz:1044-opus-13374 BibTeX | RIS


Lisa Vincenz, Richard Jäger, Michael O'Dwyer, Afshin Samali: Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma.
doi:10.1158/1535-7163.MCT-12-0782 PMID BibTeX | RIS

Richard Jäger, Howard O. Fearnhead: Mitochondrial Regulation of Cell-Death.
doi:10.1007/978-1-4614-9326-6_3 BibTeX | RIS


Richard Jäger, Howard O. Fearnhead: "Dead Cells Talking": The Silent Form of Cell Death Is Not so Quiet.
PDF Download (CC BY 3.0) doi:10.1155/2012/453838 PMID urn:nbn:de:hbz:1044-opus-9505 BibTeX | RIS

Tom Verfaillie, Richard Jäger, Afshin Samali, Patrizia Agostinis: ER Stress Signaling Pathways in Cell Survival and Death.
doi:10.1007/978-94-007-4351-9_3 BibTeX | RIS

Sandra J. M. Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis, Afshin Samali: Biology of the Endoplasmic Reticulum.
doi:10.1007/978-94-007-4351-9_1 BibTeX | RIS

Richard Jäger, Mathieu J. M. Bertrand, Adrienne M. Gorman, Peter Vandenabeele, Afshin Samali: The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.
doi:10.1111/boc.201100055 PMID BibTeX | RIS

Adrienne M. Gorman, Sandra J.M. Healy, Richard Jäger, Afshin Samali: Stress management at the ER: Regulators of ER stress-induced apoptosis.
doi:10.1016/j.pharmthera.2012.02.003 PMID BibTeX | RIS


Lisa Vincenz, Eva Szegezdi, Richard Jäger, Caitriona Holohan, Timothy OBrien, Afshin Samali: Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus.
doi:10.5772/22765 BibTeX | RIS


Richard Jäger, Ralf M. Zwacka: The enigmatic roles of caspases in tumor development.
doi:10.3390/cancers2041952 PMID BibTeX | RIS

Verena Thewes, Francesca Orso, Richard Jäger, Dawid Eckert, Sabine Schäfer, Gregor Kirfel, Stephan Garbe, Daniela Taverna, Hubert Schorle: Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells.
doi:10.1186/1471-2407-10-192 PMID BibTeX | RIS

Richard Jäger, Sabine Schäfer, Mathilde Hau-Liersch, Hubert Schorle: Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland.
doi:10.1002/dvdy.22239 PMID BibTeX | RIS


Patricia Kurth, Anne Moenning, Richard Jäger, Gaby Beine, Hubert Schorle: An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.
doi:10.1002/dvdy.21939 PMID BibTeX | RIS

Francesca Orso, Richard Jäger, Raffaele Adolfo Calogero, Hubert Schorle, Piero Sismondi, Michele de Bortoli, Daniela Taverna: AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase.
doi:10.1186/1741-7007-7-25 PMID BibTeX | RIS

Anne Moenning, Richard Jäger, Angela Egert, Wolfram Kress, Eva Wardelmann, Hubert Schorle: Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway.
doi:10.1128/MCB.00885-08 PMID BibTeX | RIS


Johannes Schenkel, Hans Weiher, Gerhard Fürstenberger, Richard Jäger: Suprabasal BCL-2 Expression Does Not Sensitize to Chemically-induced Skin Cancer in Transgenic Mice.

Richard Jäger, Leontios Pappas, Hubert Schorle: Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes.
doi:10.1186/1756-0500-1-29 PMID BibTeX | RIS


Jochen Maurer, Sebastian Fuchs, Richard Jäger, Bodo Kurz, Lukas Sommer, Hubert Schorle: Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis.
doi:10.1111/j.1432-0436.2007.00164.x PMID BibTeX | RIS

Michael Peitz, Richard Jäger, Christoph Patsch, Andrea Jäger, Angela Egert, Hubert Schorle, Frank Edenhofer: Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells.
doi:10.1002/dvg.20321 PMID BibTeX | RIS

Richard Jäger: Targeting the death machinery in mammary epithelial cells: Implications for breast cancer from transgenic and tissue culture experiments.
doi:10.1016/j.critrevonc.2007.05.006 PMID BibTeX | RIS


Dawid Eckert, Sandra Buhl, Susanne Weber, Richard Jäger, Hubert Schorle: The AP-2 family of transcription factors.
doi:10.1186/gb-2005-6-13-246 PMID BibTeX | RIS

Richard Jäger, Jens Hahne, Andrea Jacob, Angela Egert, Johannes Schenkel, Nicolas Wernert, Hubert Schorle, Axel Wellmann: Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas.

Richard Jennemann, Roger Sandhoff, Shijun Wang, Eva Kiss, Norbert Gretz, Cecilia Zuliani, Ana Martin-Villalba, Richard Jäger, Hubert Schorle, Marc Kenzelmann, Mahnaz Bonrouhi, Herbert Wiegandt, Hermann-Josef Gröne: Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth.
doi:10.1073/pnas.0500893102 BibTeX | RIS

Katharina Pauls, Richard Jäger, Susanne Weber, Eva Wardelmann, Arend Koch, Reinhard Büttner, Hubert Schorle: Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors.
doi:10.1002/ijc.20913 BibTeX | RIS

Richard Jäger, Nicolaus Friedrichs, Inge Heim, Reinhard Büttner, Hubert Schorle: Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis.
doi:10.1007/s10549-004-4815-x BibTeX | RIS


Nicolaus Friedrichs, Richard Jäger, Ellen Paggen, Christian Rudlowski, Sabine Merkelbach-Bruse, Hubert Schorle, Reinhard Buettner: Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer.
doi:10.1038/modpathol.3800292 BibTeX | RIS

Richard Jäger, Jochen Maurer, Andrea Jacob, Hubert Schorle: Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation.
doi:10.1002/gene.20014 PMID BibTeX | RIS


Richard Jäger, Uwe Werling, Stephan Rimpf, Andrea Jacob, Hubert Schorle: Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model.

M. D. Lacher, A. Siegenthaler, Richard Jäger, Xi Yan, S. Hett, L. Xuan, S. Saurer, R. R. Lareu, A. M. Dharmarajan, R. Friis: Role of DDC-4/sFRP-4, a secreted Frizzled-related protein, at the onset of apoptosis in mammary involution.
doi:10.1038/sj.cdd.4401197 BibTeX | RIS


Nadia Munarini, Richard Jäger, Susanne Abderhalden, Gisela Zuercher, Valeria Rohrbach, Saemi Loercher, Brigitte Pfanner-Meyer, Anne-Catherine Andres, Andrew Ziemiecki: Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase.


Andreas Marti, Philipp M. Ritter, Richard Jäger, Hedvika Lazar, Anna Baltzer, Johannes Schenkel, Wim Declercq, Peter Vandenabeele, Rolf Jaggi: Mouse mammary gland involution is associated with cytochrome c release and caspase activation.
doi:10.1016/S0925-4773(01)00381-1 BibTeX | RIS


Priscilla A. Furth, Ud Bar-Peled, Minglin Li, Albert Lewis, Rodolfo Laucirica, Richard Jäger, Hans Weiher, Robert G. Russell: Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model.
doi:10.1038/sj.onc.1203073 BibTeX | RIS

Kristen L. Murphy, Frances S. Kittrell, Jason P. Gay, Richard Jäger, Daniel Medina, Jeffrey M. Rosen: Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice.
doi:10.1038/sj.onc.1203099 BibTeX | RIS

Kristel Schorr, Minglin Li, Ud Bar-Peled, Albert Lewis, Alonso Heredia, Bernadette Lewis, C. Michael Knudson, Stanley J. Korsmeyer, Richard Jäger, Hans Weiher, Priscilla A. Furth: Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo.


Richard Jäger, Ute Herzer, Johannes Schenkel, Hans Weiher: Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.
doi:10.1038/sj.onc.1201353 BibTeX | RIS


Robin C. Humphreys, Maryla Krajewska, Susanne Krnacik, Richard Jäger, Hans Weiher, Stanislaw Krajewski, John C. Reed, Jeffrey M. Rosen: Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis.

Marina Schorpp, Richard Jäger, Karl Schellander, Johannes Schenkel, Erwin F. Wagner, Hans Weiher, Peter Angel: The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice.
doi:10.1093/nar/24.9.1787 PMID BibTeX | RIS