Prof. Dr. Richard Jäger

Professor für Biologie, insbesondere forensische Biologie

Kontakt

Hochschule Bonn-Rhein-Sieg
E-Mail: 
richard.jaeger [at] h-brs.de

Rheinbach

von-Liebig-Str. 20
53359
Rheinbach
Raum: 
A 274

Profil

Lehrveranstaltungen

  • Fundamentals of Biology (2. Sem. BSc Naturwissenschaftliche Forensik)
  • Forensic Biology (3. Sem. BSc Naturwissenschaftliche Forensik)
  • Fundamentals of Biology (1. Sem. MSc ACQS)
  • Programmed Cell Death (Special field, 3. Sem. MSc Biomedical Sciences)
  • Advanced Forensic DNA typing (WPF 5. Sem. BSc Naturwissenschaftliche Forensik)

Forschungsgebiete und - interessen

  • Entwicklung und Analyse forensischer DNA-Marker
  • Rolle von Zelltod in der Tumorigenese
  • transgene Tiermodelle
  • ER-Stress

Sonderaufgaben im Fachbereich

  • Mitglied des Fachbereichsrates
  • Studiengangsleiter Naturwissenschaftliche Forensik
  • Studienberatung Naturwissenschaftliche Forensik

Lebenslauf

Persönlicher Werdegang

1986-96:
Studium der Biologie, Universität Karlsruhe (Diplom und Promotion).

1997-98:
PostDoc/Assistent am Department klinische Forschung, Universität Bern.

1999-2001:
Wissenschaftl. Mitarbeiter, Institut für Genetik u. Toxikologie, Forschungszentrum Karlsruhe.

2002-2009:
Wissenschaftl. Mitarbeiter, Institut für Pathologie, Uniklinikum Bonn.

2009-2012:
Postdoctoral researcher, NCBES and Biochemistry, National University of Ireland, Galway.

Seit 2012:
Professor für Biologie an der Hochschule Bonn-Rhein-Sieg.

Publikationen

Übersichtsartikel / Review Articles

McGrath, E.P., Logue, S.E., Mnich, K., Deegan, S., Jäger, R., Gorman, A.M. & Samali, A. (2018) The Unfolded Protein Response in Breast Cancer. Cancers 10: 344.

Kennedy, D., Jäger, R., Mosser, D.D. & Samali, A. (2014) Regulation of apoptosis by heat shock proteins. IUBMB Life 66: 327–338.

Connolly, P.F., Jäger, R. & Fearnhead, H.O. (2014). New roles for old enzymes: killer caspases as the engine of cell behaviour changes. Front. Physiol. 5:149.
 
Vincenz, L., Jäger, R., O'Dwyer, M. & Samali, A. (2013) Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma. Mol. Cancer Ther., 12: 831-843.
 
Jäger, R. & Fearnhead, H.O. (2012) "Dead cells talking": The silent form of cell death is not so quiet. Biochem. Res. Int. 2012: 453838.
 
Gorman, A.M., Healy, S.J.M., Jäger, R. & Samali, A. (2012) Stress management at the ER: regulators of ER stress-induced apoptosis. Pharmacology & Therapeutics, 134: 306-316.
 
Jäger, R., Bertrand, M.J.M., Gorman, A.M., Vandenabeele, P. &Samali, A. (2012) The unfolded protein response at the crossroads of cellular life and death during ER stress. Biology of the Cell, 104: 259-270.
 
Jäger, R., Zwacka, R.M. (2010) The enigmatic roles of caspases in tumor development. Cancers 2: 1952-1979.
 
Jäger, R. (2007) Targeting the death machinery in mammary epithelial cells: implications for breast cancer from transgenic and tissue culture experiments. Critical Reviews in Oncology/Hematology 63: 231-240.
 
Eckert, D., Buhl, S., Weber, S., Jäger, R., Schorle, H. (2005) The AP-2 family of transcription factors. Genome Biology, 6: 246.1-246.8.

Originalarbeiten / Research Articles

Logue, S.E., McGrath, E.P., Cleary, P., Greene, S., Mnich, K., Almanza, A., Chevet, E., Dwyer, R.M., Oommen, A., Legembre, P., Godey, F., Madden, E.C., Leuzzi, B., Obacz, J., Zeng, Q., Patterson, J.B., Jäger, R., Gorman, A.M. & Samali, A. (2018) Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nature Commun. 15;9(1):3267.

Theunissen, G.M.G., Rolf, B., Gibb, A. & Jäger, R. (2017) DNA profiling of sperm cells by using micromanipulation and whole genome amplification. Forensic Sci Int: Genetics Suppl. 6: e497-e499.

Thewes, V., Orso, F., Jäger, R., Eckert, D., Schäfer, S., Kirfel, G., Garbe, S., Taverna, D. & Schorle, H. (2010) Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation- sensitivity in breast cancer cells. BMC Cancer 10: 192.

Jäger, R., Schäfer, S., Hau-Liersch, M. & Schorle H. (2010) Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. Dev. Dyn., 239: 1027-1033.

Orso, F., Jäger, R., Calogero, R.A., Schorle, H., Sismondi, P., De Bortololi, M. & Taverna, D. (2009) AP-2a regulates migration in GN11 neurons via a specific genetic program involving the AXL receptor tyrosine kinase. BMC Biology 7: 25.

Kurth, P., Moenning,A., Jäger, R., Beine, G. & Schorle, H. (2009) An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system. Dev. Dyn. 238: 1064-1072.

Moenning, A., Jäger, R., Egert, A., Wardelmann, E., Kress, W. & Schorle, H. (2009) Sustained platelet-derived growth factor receptor alpha signalling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Mol. Cell. Biol. 29: 881-891.

Schenkel, J., Weiher, H., Fürstenberger, G. & Jäger, R. (2008) Suprabasal bcl-2 expression does not sensitize to chemically induced skin cancer in transgenic mice. Anticancer Res. 28, 2825-2830.

Jäger, R., Pappas, L. & Schorle, H. (2008) Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. BMC Research Notes 1: 29.

Peitz, M.*, Jäger, R.*, Patsch, C., Jäger, A., Egert, A., Schorle, H. & Edenhofer, F. (2007) Improved strategy for Cre protein transduction into embryonic stem cells. Genesis 45: 508-517. * equal contribution

Maurer, M., Fuchs, S., Jäger, R., Kurz, B., Sommer, L. & Schorle, H. (2007) Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. Differentiation 75: 580-591.

Jennemann, R., Sandhoff, R., Wang, S., Kiss, E., Gretz, N., Zuliani, C., Martin-Villalba, A., Jäger, R., Schorle, H., Kenzelmann, M., Bonrouhi, M., Wiegandt, H. & Gröne, H.-J. (2005) Cell specific deletion of glucosylceramide synthase in brain leads to  severe neural defects after birth. Proc. Natl. Acad. Sci. USA 102: 12459-12464.

Jäger, R., Hahne, J., Jacob., A., Egert, A., Schenkel, J., Wernert, J., Schorle, H. & Wellmann, A. (2005) Mice transgenic for NPM-ALK develop Non-Hodgkin lymphomas. Anticancer Res. 25: 3191-3196.

Pauls, K., Jäger, R., Weber, S., Wardelmann, E., Koch, A., Büttner, R. & Schorle, H. (2005) Transcription factor AP-2g, a novel marker of gonocytes and seminomatous germ cell tumors. Int. J.     Cancer 115: 470-477.

Jäger, R., Friedrichs, N., Heim, I., Buettner, R. & Schorle, H. (2005) Dual role of AP-2g in ErbB-2-induced mammary tumorigenesis. Breast Cancer Res. Treat. 90: 273-280. 

Friedrichs, N., Jäger, R., Paggen, E., Rudlowski, C., Merkelbach-Bruse, S., Schorle, H. & Buettner, R. (2005) Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. Modern Pathol. 18: 431-438.       

Jäger, R., Maurer, J., Jacob, A. & Schorle, H. (2004) Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis 38, 145-150.

Jäger, R., Werling, U., Rimpf, S., Jacob, A. & Schorle, H. (2003) Transcription factor AP-2g stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. Mol. Cancer Res. 1: 921-929.

Lacher, M.D.., Siegenthaler, A., Jäger, R., Xi Yan, Hett, S., Xuan, L., Saurer, S., Lareu, R.R., Dharmarajan, A.M. & Friis, R. (2003) Role of DDC-4/sFRP-4, a secreted frizzled molecule, at the onset of mammary involution. Cell Death Differ. 10: 528-538.

Munarini, N.*, Jäger, R.*, Abderhalden, S., Zuercher, G., Rohrbach, V., Loercher, S., Pfanner-Meyer, B., Andres, A.-C. & Ziemiecki, A. (2002) Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase. J. Cell Sci. 115: 25-37. * equal contribution

Marti, A., Ritter, P.M., Jäger, R., Lazar, H., Baltzer, A., Schenkel, J., Declercq, W., Vandenabeele, P. & Jaggi, R. (2001) Mouse mammary gland involution is associated with cytochrome c release and caspase activation. Mech. Dev. 104: 89-98.

Murphy, K.L., Kitrell, F.S., Gay, J.P., Jäger, R., Medina, D. & Rosen, J.M. (1999) Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated mice.            Oncogene 18: 6597-6604.

Furth, P.A., Bar-Peled, U., Li, M., Lewis, A., Laucirica, R., Jäger, R., Weiher, H. & Russell, R.G. (1999) Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model. Oncogene 18: 6589-6596.

Schorr, K., Li, M., Lewis, A., Heredia, A., Lewis, B., Knudson, M., Korsmeyer, S.J., Jäger, R., Weiher, H. & Furth, P.A. (1999) Gain of Bcl-2 is more potent than Bax loss in regulating mammary epithelial cell survival in vivo. Cancer Res. 59: 2541-2545.

Jäger R., Herzer, U., Schenkel, J. & Weiher, H. (1997) Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the         mammary gland in transgenic mice. Oncogene 15: 1787-1795.

Humphreys, R.C., Krajewska, M., Krnacik, S., Jaeger, R., Weiher, H., Krajewski, S., Reed, J.C. &Rosen, J. M. (1996) Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development 122: 4013-4022.

Schorpp, M., Jäger, R., Schellander, K., Wagner, E.F., Schenkel, J., Weiher, H. & Angel, P. (1996) The human ubiquitin C promoter directs high ubiquitous expresssion of transgenes in mice. Nucleic Acids Res. 24: 1787-1788.

Buchbeiträge / Book Chapters

Kennedy, D., Samali, A. & Jäger, R. (2015) Methods for Studying ER Stress and UPR Markers in Human Cells.  Methods Mol Biol 1292: 3-18 (Springer; ISBN 978-1-4939-2521-6)

Behzad Y., Jäger R., Gorman A.M., Samali A. & Ghavami S. (2015) Induction of autophagy: role of endoplasmic reticulum stress and unfolded  protein response. In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 7 - Role of Autophagy in Therapeutic Applications (Academic Press; ISBN: 978-0128010433)

Samali, A. & Jäger, R. (2014) Mechanisms of Resistance to Cell Death Pathways in Cancer Cells. In: McManus LM, Mitchell RN (eds)​ Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, 1st edn., pp 393-402 (Elsevier; ISBN: 978-0-12-386457-4)

Jäger, R. & Fearnhead, H.O. (2013) Mitochondrial regulation of cell death. In: Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy (Springer; ISBN 978-1-4614-9325-9)

Verfaillie, T., Jäger, R., Samali, A. & Agostinis, P. (2012) ER stress signaling pathways in cell survival  and death. In: ER stress in health and disease (Springer; ISBN 978-94-007-4350-2)

Healy, S.J.M., Verfaillie, T., Jäger, R., Agostinis, P. & Samali, A. (2012) Biology of the endoplasmic reticulum. In: ER stress in health and disease (Springer; ISBN 978-94-007-4350-2)

Vincenz, L.., Szegezdi, E., Jäger, R., Holohan, C., O’Brien, T. & Samali, A. (2011) Cytokine-induced b-cell stress and death in type 1 diabetes mellitus. In: Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments (Intech; ISBN 978-953-307-756-7)