Prof. Dr. Richard Jäger

Professor für Biologie, insbesondere forensische Biologie

Kontakt

Hochschule Bonn-Rhein-Sieg
E-Mail: 
richard [dot] jaeger [at] h-brs [dot] de

Rheinbach

von-Liebig-Str. 20
53359
Rheinbach
Raum: 
A 274

Profil

Lehrveranstaltungen

Forschungsgebiete und - interessen

  • Entwicklung und Analyse forensischer DNA-Marker
  • Rolle von Zelltod in der Tumorigenese
  • transgene Tiermodelle
  • ER-Stress

Sonderaufgaben im Fachbereich

  • Mitglied des Fachbereichsrates
  • Studiengangsleiter Naturwissenschaftliche Forensik

Lebenslauf

Persönlicher Werdegang

1986-96:
Studium der Biologie, Universität Karlsruhe (Diplom und Promotion).

1997-98:
PostDoc/Assistent am Department klinische Forschung, Universität Bern.

1999-2001:
Wissenschaftl. Mitarbeiter, Institut für Genetik u. Toxikologie, Forschungszentrum Karlsruhe.

2002-2009:
Wissenschaftl. Mitarbeiter, Institut für Pathologie, Uniklinikum Bonn.

2009-2012:
Postdoctoral researcher, NCBES and Biochemistry, National University of Ireland, Galway.

Seit 2012:
Professor für Biologie an der Hochschule Bonn-Rhein-Sieg.

Publikationen

Übersichtsartikel / Review Articles

Kennedy, D., Jäger, R., Mosser, D.D. & Samali, A. (2014) Regulation of apoptosis by heat shock proteins. IUBMB Life 66: 327–338

Connolly, P.F., Jäger, R. & Fearnhead, H.O. (2014). New roles for old enzymes: killer caspases as the engine of cell behaviour changes. Front. Physiol. 5:149
 
Vincenz, L., Jäger, R., O'Dwyer, M. & Samali, A. (2013) Endoplasmic reticulum stress and the unfolded protein response: targeting the Achilles heel of multiple myeloma. Mol. Cancer Ther., 12: 831-843.
 
Jäger, R. & Fearnhead, H.O. (2012) "Dead cells talking": The silent form of cell death is not so quiet. Biochem. Res. Int. 2012: 453838
 
Gorman, A.M., Healy, S.J.M., Jäger, R. & Samali, A. (2012) Stress management at the ER: regulators of ER stress-induced apoptosis. Pharmacology & Therapeutics, 134: 306-316.
 
Jäger, R., Bertrand, M.J.M., Gorman, A.M., Vandenabeele, P. &Samali, A. (2012) The unfolded protein response at the crossroads of cellular life and death during ER stress. Biology of the Cell, 104: 259-270.
 
Jäger, R., Zwacka, R.M. (2010) The enigmatic roles of caspases in tumor development. Cancers 2: 1952-1979.
 
Jäger, R. (2007) Targeting the death machinery in mammary epithelial cells: implications for breast cancer from transgenic and tissue culture experiments. Critical Reviews in Oncology/Hematology 63: 231-240.
 
Eckert, D., Buhl, S., Weber, S., Jäger, R., Schorle, H. (2005) The AP-2 family of transcription factors. Genome Biology, 6: 246.1-246.8.

Originalarbeiten / Research Articles

Thewes, V., Orso, F., Jäger, R., Eckert, D., Schäfer, S., Kirfel, G., Garbe, S., Taverna, D. & Schorle, H. (2010) Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation- sensitivity in breast cancer cells. BMC Cancer 10: 192.

 

Jäger, R., Schäfer, S., Hau-Liersch, M. & Schorle H. (2010) Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. Dev. Dyn., 239: 1027-1033.

 

Orso, F., Jäger, R., Calogero, R.A., Schorle, H., Sismondi, P., De Bortololi, M. & Taverna, D. (2009) AP-2a regulates migration in GN11 neurons via a specific genetic program involving the AXL receptor             tyrosine kinase. BMC Biology 7: 25.

 

Kurth, P., Moenning,A., Jäger, R., Beine, G. & Schorle, H. (2009) An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system. Dev. Dyn. 238: 1064-1072.

 

Moenning, A., Jäger, R., Egert, A., Wardelmann, E., Kress, W. & Schorle, H. (2009) Sustained platelet-derived growth factor receptor alpha signalling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Mol. Cell. Biol. 29: 881-891.

 

Schenkel, J., Weiher, H., Fürstenberger, G. & Jäger, R. (2008) Suprabasal bcl-2 expression does not sensitize to chemically induced skin cancer in transgenic mice. Anticancer Res. 28, 2825-2830.

 

Jäger, R., Pappas, L. & Schorle, H. (2008) Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. BMC Research Notes 1: 29.

 

Peitz, M.*, Jäger, R.*, Patsch, C., Jäger, A., Egert, A., Schorle, H. & Edenhofer, F. (2007) Improved strategy for Cre protein transduction into embryonic stem cells. Genesis 45: 508-517. * equal contribution

 

Maurer, M., Fuchs, S., Jäger, R., Kurz, B., Sommer, L. & Schorle, H. (2007) Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. Differentiation 75: 580-591.

 

Jennemann, R., Sandhoff, R., Wang, S., Kiss, E., Gretz, N., Zuliani, C., Martin-Villalba, A., Jäger, R., Schorle, H., Kenzelmann, M., Bonrouhi, M., Wiegandt, H. & Gröne, H.-J. (2005) Cell specific deletion of glucosylceramide synthase in brain leads to  severe neural defects after birth. Proc. Natl. Acad. Sci. USA 102: 12459-12464.

 

Jäger, R., Hahne, J., Jacob., A., Egert, A., Schenkel, J., Wernert, J., Schorle, H. & Wellmann, A. (2005) Mice transgenic for NPM-ALK develop Non-Hodgkin lymphomas. Anticancer Res. 25: 3191-3196.

 

Pauls, K., Jäger, R., Weber, S., Wardelmann, E., Koch, A., Büttner, R. & Schorle, H. (2005) Transcription factor AP-2, a novel marker of gonocytes and seminomatous germ cell tumors. Int. J.     Cancer 115: 470-477.

 

Jäger, R., Friedrichs, N., Heim, I., Buettner, R. & Schorle, H. (2005) Dual role of AP-2g in ErbB-2-induced mammary tumorigenesis. Breast Cancer Res. Treat. 90: 273-280. 

 

Friedrichs, N., Jäger, R., Paggen, E., Rudlowski, C., Merkelbach-Bruse, S., Schorle, H. &Buettner, R. (2005) Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. Modern Pathol. 18: 431-438.

           

Jäger, R., Maurer, J., Jacob, A. & Schorle, H. (2004) Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation.Genesis 38, 145-150.

 

Jäger, R., Werling, U., Rimpf, S., Jacob, A. & Schorle, H. (2003) Transcription factor AP-2 stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. Mol. Cancer Res. 1: 921-929.

 

Lacher, M.D.., Siegenthaler, A., Jäger, R., Xi Yan, Hett, S., Xuan, L., Saurer, S., Lareu, R.R., Dharmarajan, A.M. & Friis, R. (2003) Role of DDC-4/sFRP-4, a secreted frizzled molecule, at the onset of mammary involution. Cell Death Differ. 10: 528-538.

 

Munarini, N.*, Jäger, R.*, Abderhalden, S., Zuercher, G., Rohrbach, V., Loercher, S., Pfanner-Meyer, B., Andres, A.-C. & Ziemiecki, A. (2002) Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase. J. Cell Sci. 115: 25-37. * equal contribution

 

Marti, A., Ritter, P.M., Jäger, R., Lazar, H., Baltzer, A., Schenkel, J., Declercq, W., Vandenabeele, P. & Jaggi, R. (2001) Mouse mammary gland involution is associated with cytochrome c release and caspase activation. Mech. Dev. 104: 89-98.

 

Murphy, K.L., Kitrell, F.S., Gay, J.P., Jäger, R., Medina, D. & Rosen, J.M. (1999) Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated mice.            Oncogene 18: 6597-6604.

 

Furth, P.A., Bar-Peled, U., Li, M., Lewis, A., Laucirica, R., Jäger, R., Weiher, H. & Russell, R.G.            (1999) Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model. Oncogene 18: 6589-6596.

 

Schorr, K., Li, M., Lewis, A., Heredia, A., Lewis, B., Knudson, M., Korsmeyer, S.J., Jäger, R., Weiher, H. & Furth, P.A. (1999) Gain of Bcl-2 is more potent than Bax loss in regulating mammary epithelial cell survival in vivo. Cancer Res. 59: 2541-2545.

 

Jäger R., Herzer, U., Schenkel, J. & Weiher, H. (1997) Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the         mammary gland in transgenic mice. Oncogene 15: 1787-1795.

 

Humphreys, R.C., Krajewska, M., Krnacik, S., Jaeger, R., Weiher, H., Krajewski, S., Reed, J.C. &Rosen, J. M. (1996) Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development 122: 4013-4022.

 

Schorpp, M., Jäger, R., Schellander, K., Wagner, E.F., Schenkel, J., Weiher, H. & Angel, P. (1996) The human ubiquitin C promoter directs high ubiquitous expresssion of transgenes in mice. Nucleic Acids Res. 24: 1787-1788.

Buchbeiträge / Book Chapters

Kennedy, D., Samali, A. & Jäger, R. (2015) Methods for Studying ER Stress and UPR Markers in Human Cells.  Methods Mol Biol 1292: 3-18 (Springer; ISBN 978-1-4939-2521-6)

 

Behzad Y., Jäger R., Gorman A.M., Samali A. & Ghavami S. (2015) Induction of autophagy: role of endoplasmic reticulum stress and unfolded  protein response. In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 7 - Role of Autophagy in Therapeutic Applications (Academic Press; ISBN: 978-0128010433)

 

Samali, A. & Jäger, R. (2014) Mechanisms of Resistance to Cell Death Pathways in Cancer Cells. In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (Elsevier; ISBN: 978-0-12-386457-4)

 

Jäger, R. & Fearnhead, H.O. (2013) Mitochondrial regulation of cell death. In: Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy (Springer; ISBN 978-1-4614-9325-9)

 

Verfaillie, T., Jäger, R., Samali, A. & Agostinis, P. (2012) ER stress signaling pathways in cell survival  and death. In: ER stress in health and disease (Springer; ISBN 978-94-007-4350-2)

 

Healy, S.J.M., Verfaillie, T., Jäger, R., Agostinis, P. & Samali, A. (2012) Biology of the endoplasmic reticulum. In: ER stress in health and disease (Springer; ISBN 978-94-007-4350-2)

 

Vincenz, L.., Szegezdi, E., Jäger, R., Holohan, C., O’Brien, T. & Samali, A. (2011) Cytokine-induced b-cell stress and death in type 1 diabetes mellitus. In: Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments (Intech; ISBN 978-953-307-756-7)