Prof. Dr. Ralf Thiele

Angewandte Informatik insb. Bioinformatik

Kontakt

Ralf Thiele
E-Mail: 
ralf.thiele [at] h-brs.de

Sankt Augustin

Grantham-Allee 20
53757
Sankt Augustin
Raum: 
C 255

Profil

Forschungsgebiete

  • Bioinformatik
  • Chemoinformatik
  • Computational Biology
  • Text Mining
  • Optimierung
  • Algorithmen in naturwissenschaftlichen und technischen Anwendungen

Funktionen

  • Gutachter für die ASIIN

Projekte

Abschlussarbeiten & Projekte

Die folgenden Arbeiten habe ich in den letzten Jahren betreut bzw. betreue ich aktuell. Die Themen geben einen guten Überblick über die Forschungsgebiete, die mich besonders interessieren.

Publikationen

Prof. Dr. Ralf Thiele

2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2008 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992

2018

Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Klötgen, Michael Gombert, Ute Fischer, Daniel Schäfer, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Cornelia Eckert, Arndt Borkhardt, Roland Meisel: Whole-Exome-Sequencing identifiziert hohe Plastizität, Selektionsdruck und „druggable targets“ in Leukämiezellen pädiatrischer ALL Rezidive nach allogener Stammzelltransplantation.
URL BibTeX | RIS

2016

Maria Joosten, Sebastian Ginzel, Christian Blex, Dmitri Schmidt, Michael Gombert, Cai Chen, René Martin Linka, Olivia Gräbner, Anika Hain, Burkhard Hirsch, Anke Sommerfeld, Anke Seegebarth, Uschi Gruber, Corinna Maneck, Langhui Zhang, Katharina Stenin, Henrik Dieks, Michael Sefkow, Carsten Münk, Claudia D. Baldus, Ralf Thiele, Arndt Borkhardt, Michael Hummel, Hubert Köster, Ute Fischer, Mathias Dreger, Volkhard Seitz: A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.
doi:10.1016/j.molonc.2016.06.001 BibTeX | RIS

2015

Alberto Martin-Lorenzo, Julia Hauer, Carolina Vicente-Duenas, Franziska Auer, Ines Gonzalez-Herrero, Idoia Garcia-Ramirez, Sebastian Ginzel, Ralf Thiele, Stefan N. Constantinescu, Christoph Bartenhagen, Martin Dugas, Michael Gombert, Daniel Schafer, Oscar Blanco, Andrea Mayado, Alberto Orfao, Diego Alonso-Lopez, Javier de Las Rivas, Cesar Cobaleda, Maria Begona Garcia-Cenador, Francisco Javier Garcia-Criado, Isidro Sanchez-Garcia, Arndt Borkhardt: Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility.
doi:10.1158/2159-8290.CD-15-0892 BibTeX | RIS

Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Hönscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer: Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease.
doi:10.3324/haematol.2014.114967 BibTeX | RIS

Ute Fischer, Michael Forster, Anna Rinaldi, Thomas Risch, Stéphanie Sungalee, Hans-Jörg Warnatz, Beat Bornhauser, Michael Gombert, Christina Kratsch, Adrian M. Stütz, Marc Sultan, Joelle Tchinda, Catherine L. Worth, Vyacheslav Amstislavskiy, Nandini Badarinarayan, André Baruchel, Thies Bartram, Giuseppe Basso, Cengiz Canpolat, Gunnar Cario, Hélène Cavé, Dardane Dakaj, Mauro Delorenzi, Maria Pamela Dobay, Cornelia Eckert, Eva Ellinghaus, Sabrina Eugster, Viktoras Frismantas, Sebastian Ginzel, Oskar A. Haas, Olaf Heidenreich, Georg Hemmrich-Stanisak, Kebria Hezaveh, Jessica I. Höll, Sabine Hornhardt, Peter Husemann, Priyadarshini Kachroo, Christian P. Kratz, Geertruy Te Kronnie, Blerim Marovca, Felix Niggli, Alice C. McHardy, Anthony V. Moorman, Renate Panzer-Grümayer, Britt S. Petersen, Benjamin Raeder, Meryem Ralser, Philip Rosenstiel, Daniel Schäfer, Martin Schrappe, Stefan Schreiber, Moritz Schütte, Björn Stade, Ralf Thiele, Nicolas von der Weid: Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
doi:10.1038/ng.3362 BibTeX | RIS

Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Silja Röttgers, Jutta Bradtke, Andrea Teigler-Schlegel, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Peter Husemann, Pina F.I. Krell, Arndt Borkhardt, Martin Dugas, Jianda Hu, Ute Fischer: Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
doi:10.1016/j.leukres.2015.06.005 BibTeX | RIS

2014

J. I. Hoell, M. Gombert, S. Ginzel, S. Loth, P. Landgraf, V. Käfer, M. Streiter, A. Prokop, M. Weiss, R. Thiele, A. Borkhardt: Constitutional Mismatch Repair-deficiency and Whole-exome Sequencing as the Means of the Rapid Detection of the Causative MSH6 Defect.
doi:10.1055/s-0034-1389905 BibTeX | RIS

2013

Y. Linka, S. Ginzel, M. Krüger, A. Novosel, M. Gombert, E. Kremmer, J. Harbott, R. Thiele, A. Borkhardt, P. Landgraf: The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods.
doi:10.1038/bcj.2013.48 BibTeX | RIS

Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Andrea Teigler-Schlegel, Jutta Bradtke, Silja Roettgers, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Martin Dugas, Jianda Hu, Arndt Borkhardt, Ute Fischer: Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic Leukemia.
URL BibTeX | RIS

Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Silja Roettgers, Jutta Bradtke, Andrea Teigler-Schlegel, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Ute Fischer, Martin Dugas, Jianda Hu, Arndt Borkhardt: Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia.
doi:10.1002/gcc.22054 BibTeX | RIS

2012

Vera Okpanyi, Christoph Bartenhagen, Michael Gombert, Sebastian Ginzel, Pina Fanny Ida Krell, Peter Husemann, Cai Chen, Vera Binder, Jutta Bradtke, Andrea Teigler-Schlegel, Silja Roettgers, Jochen Harbott, Martin Stanulla, Cornelia Eckert, Ralf Thiele, Martin Dugas, Arndt Borkhardt, Ute Fischer: Novel Genomic Structural Variations in Relapsed Childhood ETV6/RUNX1 (TEL/AML1) Acute Lymphoblastic Leukemias Identified by Next Generation Sequencing.
URL BibTeX | RIS

2008

Robert Pesch, Artem Lysenko, Matthew Hindle, Keywan Hassani-Pak, Ralf Thiele, Christopher Rawlings, Jacob Kohler, Jan Taubert: Graph-based sequence annotation using a data integration approach.
doi:10.2390/biecoll-jib-2008-94 doi:10.1515/jib-2008-94 BibTeX | RIS

1999

Ralf Thiele, Ralf Zimmer, Thomas Lengauer: Protein threading by recursive dynamic programming.
doi:10.1006/jmbi.1999.2893 BibTeX | RIS

1998

Ralf Zimmer, Marko Wöhler, Ralf Thiele: New scoring schemes for protein fold recognition based on Voronoi contacts.
doi:10.1093/bioinformatics/14.3.295 BibTeX | RIS

1997

Ralf Zimmer, Ralf Thiele: Fast protein fold recognition and accurate sequence-structure alignment.
doi:10.1007/BFb0033212 BibTeX | RIS

1996

T. Lengauer, R. Thiele, R. Zimmer: Modellierung von Proteinstrukturen.
BibTeX | RIS

1995

Ralf Thiele, Ralf Zimmer, Thomas Lengauer: Recursive Dynamic Programming for Adaptive Sequence and Structure Alignment.
BibTeX | RIS

H. Schmidt, D. Theune, R. Thiele, T. Lengauer: EMC-driven midway routing on PCBs.
doi:10.1109/EDTC.1995.470357 BibTeX | RIS

1994

H. Mevissen, R. Thiele, R. Zimmer, T. Lengauer: The ToPLign Software Environment - Toolbox for Preotein Alignment.
BibTeX | RIS

D. Theune, R. Thiele, W. John, T. Lengauer: Robust methods for EMC-driven routing.
doi:10.1109/43.329265 BibTeX | RIS

1993

W. John, D. Theune, R. Thiele: Layout design for printed-circuit boards under EMC-constraints.
BibTeX | RIS

1992

Dirk Theune, Ralf Thiele, Thomas Lengauer, Anja Feldmann: HERO: Hierarchical EMC-constrained routing.
doi:10.1109/ICCAD.1992.279326 BibTeX | RIS